钛合金表面生物活性涂层及成骨效果的研究与进展

发布时间：2018-04-04 20:14

本文选题：钛　切入点：合金　出处：《中国组织工程研究》2017年06期

【摘要】：背景:医用钛合金作为骨科常用修复材料,其具有良好的生物相容性和力学支撑,但缺乏骨整合能力,表面生物活性涂层修饰可以改善其生物学性能。目的:综述钛合金表面修饰中生物活性涂层技术的应用进展,探讨其促进骨生成的机制。方法:检索Pub Med数据库和CNKI数据库,中文关键词为"钛,钛合金,涂层,表面修饰,骨组织",英文关键词为"titanium,titanium alloy,coating,surface modification,bone",时间限定为2000年1月至2016年3月。在结果中初步分析,筛选出有关钛合金表面涂层修饰的相关文章42篇。结果与结论:钛合金表面修饰技术经历了从表面粗化、氧化、酸化的处理方式向目前应用最广泛的生物活性涂层技术的转变。在钛合金表面生物活性涂层中,主要有羟基磷灰石涂层、生物活性玻璃涂层、分子筛涂层等,且已经从单一涂层发展到复合涂层和梯度涂层,同时在涂层中负载生物活性因子或金属离子,可以完善钛合金表面生物活性涂层的骨诱导性能。钛合金表面修饰是个复杂的过程,既要考虑改性后涂层促进骨生成的能力,还要考虑涂层与基底钛合金结合强度。对现有生物活性涂层制备方式的改善以及生物活性涂层新材料的进一步探索,是实现优质表面生物活性涂层修饰的关键。
[Abstract]:Background: medical titanium alloy is commonly used as orthopedic repair material, it has good biocompatibility and mechanical support, but lack of bone integration ability, surface bioactive coating modification can improve its biological properties.Aim: to review the application of bioactive coating technology in titanium alloy surface modification and explore its mechanism of promoting bone formation.Methods: Pub Med database and CNKI database were searched. The Chinese key words were "titanium, titanium alloy, coating, surface modification, bone tissue", and the English key word was "titanium-titanium titanium alloying surface modification bone", which was limited from January 2000 to March 2016.From the preliminary analysis of the results, 42 articles on surface coating modification of titanium alloy were selected.Results & conclusion: the surface modification technology of titanium alloy has changed from coarsening, oxidation and acidification to the most widely used bioactive coating technology.Among the bioactive coatings on titanium alloy, there are mainly hydroxyapatite coating, bioactive glass coating, molecular sieve coating and so on, and have developed from single coating to composite coating and gradient coating.At the same time, loading bioactive factors or metal ions into the coating can improve the bone induction properties of the bioactive coating on titanium alloy surface.The surface modification of titanium alloy is a complicated process, which not only considers the ability of the modified coating to promote bone formation, but also considers the bonding strength between the coating and the substrate titanium alloy.The improvement of the preparation methods of bioactive coatings and the further exploration of new materials for bioactive coatings are the key to realize the modification of high quality surface bioactive coatings.
【作者单位】：吉林大学第二医院;
【基金】：吉林省省级产业专业创新专项资金项目(2016C037) 吉林省科技发展计划项目(20150414006G H)~~
【分类号】：R318.08;R68

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