镁合金支架在兔腹主动脉中的降解

发布时间：2018-04-05 04:21

本文选题：主动脉　切入点：腹　出处：《中国组织工程研究》2017年18期

【摘要】：背景:国外研究发现镁合金支架是安全有效的,国内对于镁合金支架降解性能的研究不多。目的:探讨可降解AZ31镁合金支架在兔腹主动脉中的降解情况及降解过程对血管的影响。方法:在28只新西兰大白兔腹主动脉植入可降解AZ31镁合金支架,在植入的30,60,90,120 d进行X射线检查及支架植入段血管组织学观察。结果与结论:(1)X射线检查:植入后30 d,支架完全扩张,结构完整;植入后60 d,支架变形,部分支架断裂,失去支撑作用;植入后90 d,只有少量支架支杆残留,大部分支架已降解;植入后120 d,血管中无支架支杆残留,支架已完全降解;(2)组织学观察结果:植入后60 d的剩余支架支杆数小于植入后30 d(P0.05),植入后90 d的剩余支架支杆数小于植入后30,60 d(P0.05),植入后120 d的剩余支架支杆数小于植入后30,60,90 d(P0.05);剩余支杆数和天数呈负相关,支架完全降解天数为植入后124.8 d。植入90 d的血管内膜面积大于植入后30,60,120 d(P0.05),血管管腔面积小于小于植入后30,60,120 d(P0.05);后3个时间点的血管内膜面积与血管管腔面积比较差异无显著性意义;(3)结果表明,可降解AZ31镁合金支架在大白兔腹主动脉内完全降解时间为124.8 d,在支架植入90 d时血管内膜增生和管腔狭窄最明显,90 d后血管内膜增生和管腔狭窄逐渐减轻。
[Abstract]:Background: the foreign study found that magnesium alloy stent is safe and effective, the research on the degradation performance of magnesium alloy is not much. Objective: To study the effect of degradation and the degradation process of AZ31 magnesium alloy stent in rabbit abdominal aorta in the vascular. Methods: in 28 New Zealand rabbits were implanted in abdominal aorta the degradation of AZ31 magnesium alloy stent, X X-ray examination and histological observation of vascular stent implantation in the implanted 30,60,90120 D. Results and conclusion: (1) X ray examination: after the implantation of 30 d stent expansion, structural integrity; 60 d after implantation, stent deformation, partial stent fracture, lost support; implantation after 90 d, only a small amount of support rod residues, most stents have been implanted after degradation; 120 d, no support rod residues in vascular stents have been completely degraded; (2) histological observation: after implantation of the remaining support rod number 60 d less than after implantation 30 d (P0.05), after the implantation of the remaining support rod number 90 d less than 30,60 after implantation of D (P0.05), after the implantation of the remaining support rod number 120 d less than 30,60,90 after implantation of D (P0.05); the remaining negative correlation pole number and number of days, days after the implantation of stents completely degraded 124.8 D. plant the intimal area is 90 d greater than 30,60120 after implantation D (P0.05), lumen area is less than D less than 30,60120 after implantation (P0.05); no significant difference after 3 time points of the vascular intimal area and lumen area difference; (3) the results show that the complete degradation time degradation of AZ31 magnesium alloy stent in the rabbit abdominal aorta was 124.8 D and 90 d in stent neointimal hyperplasia and lumen stenosis was 90 d after vascular intimal hyperplasia and lumen stenosis gradually reduced.

【作者单位】：郑州大学第五附属医院血管外科;
【基金】：河南省卫生厅项目(WZ-201202015) 河南省教育厅项目(16B320023)~~
【分类号】：R318.08;R654.3

【参考文献】