钛合金表面抗菌涂层:抗菌能力及生物相容性

发布时间：2018-04-23 23:02

本文选题：生物相容性材料 + 钛　；参考：《中国组织工程研究》2015年25期

【摘要】：背景:钛合金材料因具有良好的生物相容性、耐腐蚀性和综合力学性能被广泛用于临床,如何赋予其优良的抗菌性以应对内植物相关感染是近年来的研究热点。目的:综述了钛合金表面抗菌涂层的原理、技术、分类及优缺点。方法:由第一作者检索1990年1月至2014年1月Scopus数据库、中国科技期刊数据库(重庆维普)相关文献,检索关键词为"Titanium alloy,Plant,Antibacterial,Coating;钛合金,内植物,抗菌,涂层"。结果与结论:根据涂层的种类可将其分为抗生素类涂层、非抗生素类有机抗菌剂涂层、无机抗菌剂类涂层、抗黏附性涂层、抗菌生物活性聚合物涂层,各种涂层均具有较好的生物相容性,但也有各自的局限,目前对抗菌涂层的研究主要集中于:如何增强抗菌涂层与基体的结合力,并获得良好的抗菌性、生物相容性、高耐磨性、持久性是需要研究的关键问题;抗菌相结构、分布对于细菌定植的研究,无论是合金整体添加抗菌元素还是表面涂层型钛合金,抗菌相的结构、分布是影响抗菌性能的关键因素。
[Abstract]:Background: titanium alloy materials have been widely used in clinic because of their good biocompatibility, corrosion resistance and comprehensive mechanical properties. Objective: to summarize the principle, technology, classification, advantages and disadvantages of antibacterial coating on titanium alloy surface. Methods: from January 1990 to January 2014, Scopus database and Chinese Journal of Science and Technology Database (Chongqing Weipu) were searched by the first author. The key words were "Titanium alloyr Plantantibacter Coating.Titanium alloy, endophyte, antibacterial, coating". Results & conclusion: the coatings can be classified into antibiotic coatings, non-antibiotic organic antibacterial coatings, inorganic antimicrobial coatings, anti-adhesion coatings and antibacterial bioactive polymer coatings. All kinds of coatings have good biocompatibility, but they also have their own limitations. At present, the research on antibacterial coatings is mainly focused on: how to enhance the adhesion between antibacterial coatings and substrate, and obtain good antibacterial and biocompatibility. High wear resistance and durability are the key problems to be studied; the structure and distribution of antibacterial phase, whether the antibacterial element is added to the whole alloy or the surface coated titanium alloy, the structure of the antibacterial phase, Distribution is the key factor affecting antibacterial properties.
【作者单位】：哈尔滨医科大学附属第一医院骨外科;哈尔滨工业大学;
【分类号】：R318.08

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