类肝素聚乳酸微孔膜的血液相容性

发布时间：2018-04-23 23:15

本文选题：类肝素 + 聚乳酸膜　；参考：《工程塑料应用》2017年04期

【摘要】：通过在生物基聚乳酸(PLA)膜表面进行类肝素化修饰,得到了具有良好血液相容性的生物基聚合物膜。首先通过自由基聚合合成了聚(乙烯基吡咯烷酮乙烯基三乙氧基硅烷)[P(VP VTES)]预聚物,进一步通过其界面交联,将高含量的聚乙烯基吡咯烷酮固化到PLA膜表面,提高膜表面的亲水性和抗污性能。其次通过自由基聚合合成类肝素预聚物苯乙烯磺酸钠乙烯基三乙氧基硅烷丙烯酸三元共聚物[P(SSNa VTES AAH)],并利用预聚物中VTES链段的水解缩合反应将类肝素共聚物固定在PLA膜表面,从而提高膜的血液相容性。通过红外光谱确定了PLA膜表面亲水层P(VP VTES)和P(SSNa VTES AAH)的分子结构。通过接触角测试表明类肝素分子修饰的PLA膜具有良好的亲水性,并可以抑制膜表面血小板的吸附和聚集。同时,凝血测试结果表明类肝素分子修饰的PLA膜表面具有良好的血液相容性。
[Abstract]:A biodegradable polymer membrane with good blood compatibility was obtained by heparin-like modification on the surface of biologically based polylactic acid (PLA) membrane. Poly (vinylpyrrolidone triethoxy silane) [P(VP VTEs] prepolymer was synthesized by free radical polymerization. The high content of polyvinylpyrrolidone was cured onto the surface of PLA film by interfacial crosslinking. The hydrophilicity and antifouling property of the membrane surface were improved. Secondly, heparin prepolymer sodium styrene-sulfonate triethoxy silane acrylic acid terpolymer (P(SSNa / VTES) was synthesized by free radical polymerization. The heparin was copolymerized by hydrolysis and condensation of VTES segment in the prepolymer. The matter was immobilized on the surface of the PLA membrane. So as to improve the blood compatibility of the membrane. The molecular structures of the hydrophilic layers of PLA films, P(VP and P(SSNa VTES, were determined by IR spectra. The contact angle test showed that heparin-like molecular modified PLA membrane had good hydrophilicity and could inhibit the adsorption and aggregation of platelet on the membrane surface. At the same time, the results of coagulation test showed that the surface of PLA membrane modified by heparin had good blood compatibility.
【作者单位】：青岛科技大学高分子科学与工程学院;中国科学院宁波材料技术与工程研究所;
【基金】：国家自然科学基金面上项目(51473177) 中国科学院青年创新促进会项目(2014258)
【分类号】：TQ317;R318.08

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