生物医用钛表面一维纳米结构的制备及功能改性

发布时间：2018-04-25 19:29

本文选题：生物医用钛 + 表面改性　；参考：《湖北大学》2014年硕士论文

【摘要】：生物医用钛金属材料由于其良好的力学性能、易加工性、与人骨相近的弹性模量、耐腐蚀性和良好的生物相容性被广泛应用于人工骨关节、骨钉、牙种植体等硬组织材料。但是,钛及钛合金存在生物惰性的缺点,植入人体后与周围组织不能达到骨性结合,只是简单的机械锁合,易被纤维组织包裹与宿主组织隔离,长此以往会引起血栓而导致植入失败。另外,在临床手术中,细菌感染是很常见的一大问题,全面的消毒和无菌操作仍然避免不了术后感染的发生。临床上主要解决途径是注射抗生素,但抗生素注射具有特异性,需长期注射且会产生抗药菌株。基于以上问题,本论文提出在钛金属表面构建功能化的纳米结构,运用水热处理法在钛片表面原位生长出一维纳米相结构,提高材料生物相容性,增加材料的粗糙度和比表面积,为后续掺杂银纳米粒子提供附着位点；通过体外仿生矿化在材料表面沉积羟基磷灰石涂层增强材料生物活性；在钛酸盐纳米结构上载入Ag纳米颗粒制备出兼具生物相容性和抑菌性能的多功能复合型植入材料。具体包括如下工作： 1.钛金属表面一维纳米结构的制备、影响因素及生长机理的研究 2.在含钛酸盐纳米结构的钛表面掺杂银离子提高材料抗菌性能 3.一维纳米相修饰后的样品表面生物矿化及表面特征 4.水热处理后的样品及掺银样品的体外细胞实验研究结果表明：通过水热法可以在钛基表面制备出形貌均一,涂层均匀的钛酸盐一维纳米结构薄膜,反应温度和碱液浓度均对材料表面微观形貌有影响；最佳水热工艺条件为纯钛片与0.2M NaOH在180°C下反应72小时得到纳米针状改性表面；通过紫外光化学法可以在材料表面载银,银纳米颗粒在钛基表面分布均匀,随着硝酸银溶液浓度的增加,抗菌效果更好；水热处理后的材料表面能够引导羟基磷灰石在表面沉积,并且能够有效提高早期细胞在材料表面的增殖与分化。
[Abstract]:Biomedical titanium metal materials are widely used in artificial bone joints, bone nails, dental implants and other hard tissue materials due to their good mechanical properties, easy processing, similar to human bone elastic modulus, corrosion resistance and good biocompatibility. However, titanium and titanium alloys have the disadvantage of biological inert, after implanted into the human body and the surrounding tissues can not achieve osseous binding, but simply mechanical locking, easy to be wrapped in fibrous tissue and isolated from the host tissue. In the long run, it can cause thrombus and lead to the failure of implantation. In addition, bacterial infection is a common problem in clinical surgery. In clinic, the main solution is to inject antibiotics, but antibiotic injection is specific, need long-term injection and will produce drug-resistant strains. Based on the above problems, this paper proposes to construct functional nanostructures on the surface of titanium, and to improve the biocompatibility of the materials by in situ growth of one-dimensional nanostructures on the surface of titanium by hydrothermal treatment. Increase the roughness and specific surface area of the material, provide the attachment site for the subsequent doped silver nanoparticles, and enhance the bioactivity of the material by biomimetic mineralization deposition of hydroxyapatite coating on the material surface in vitro. A multifunctional composite implant material with biocompatibility and bacteriostasis was prepared by loading Ag nanoparticles on titanate nanostructures. These include the following: 1. Preparation, influencing factors and growth Mechanism of One-Dimensional Nanostructures on Titanium Surface 2. Doping Silver Ion on Titanium Surface containing Titanate Nanostructures to improve Antibacterial Properties 3. Surface biomineralization and surface characteristics of one-dimensional nano-phase modified samples 4. In Vitro Cell experiment of samples after hydrothermal treatment and Silver doped samples The results show that the surface morphology of titanium substrate can be uniform by hydrothermal method, and the one-dimensional nanostructured titanate thin films with uniform coating can be prepared. The reaction temperature and the concentration of alkali have an effect on the surface morphology of the materials. The optimum hydrothermal conditions were as follows: the pure titanium sheet reacted with 0.2 M NaOH at 180 掳C for 72 hours to obtain the needle modified surface, and the silver nanoparticles could be loaded on the surface of the material by ultraviolet photochemistry, and the silver nanoparticles distributed uniformly on the surface of titanium substrate. With the increase of the concentration of silver nitrate solution, the antibacterial effect is better, and the surface of the material after hydrothermal treatment can lead to hydroxyapatite deposition on the surface, and can effectively improve the proliferation and differentiation of early cells on the surface of the material.
【学位授予单位】：湖北大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：TG178;R318.08

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