干细胞3D支架的研究进展

发布时间：2018-05-01 12:02

本文选题：干细胞 + D微环境　；参考：《中国生物工程杂志》2017年09期

【摘要】：干细胞是一类具有无限增殖潜能,可自我更新的细胞,不同的培养或诱导条件下能够分化成为不同的细胞类型。目前,随着医学治疗手段及干细胞研究的不断发展,发现干细胞可应用于很多疾病的治疗,干细胞临床应用日益广泛,逐渐成为科研工作者研究的热点。然而干细胞移植进入生物体后繁殖效率很低,无法达到需求的量,因此如何对干细胞在生物体外进行大量培养扩增、在生物体内如何更稳定地增殖分化成为迫切需要解决的难题。当前干细胞最主要的培养方法仍是2D培养,2D培养无法模拟体内的3D微环境,繁殖效率较低,正是由于2D培养局限性太多,促使国内外学者对3D培养技术和3D支架材料进行深入探索,并取得了大量成果。对3D培养技术在干细胞中的发展与应用进行概述和展望。
[Abstract]:Stem cells are a kind of cells with unlimited proliferative potential and self-renewal. They can differentiate into different cell types under different culture or induction conditions. At present, with the development of medical treatment and stem cell research, it is found that stem cells can be used in the treatment of many diseases. However, stem cell transplantation into the organism after reproduction efficiency is very low, can not reach the required amount, so how to expand the stem cells in vitro culture in a large number of organisms, How to more steadily proliferate and differentiate in organisms has become an urgent problem to be solved. At present, the main method of stem cell culture is that 2D culture can't simulate 3D microenvironment in vivo, and its reproductive efficiency is low, because 2D culture has too many limitations. In order to promote the domestic and foreign scholars to explore the 3D culture technology and 3D scaffold materials, and achieved a lot of results. The development and application of 3D culture technology in stem cells were reviewed and prospected.
【作者单位】：温州医科大学附属第一医院;
【基金】：温州市公益性科技计划项目(Y20150042) 浙江省医药卫生重大科技计划(WKJ2013-2-022) 浙江省医药卫生科技计划(2016RCA022)资助项目
【分类号】：R318.08

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