基于髓过氧化物酶的分子探针成像研究进展

发布时间：2018-05-01 11:22

本文选题：髓过氧化物酶 + 炎症　；参考：《放射学实践》2017年09期

【摘要】：髓过氧化物酶(MPO)是许多炎症相关疾病的重要标志物,包括动脉粥样硬化、血管炎、中风、肿瘤、帕金森病、阿尔茨海默病、多发性硬化等。MPO可以作为一个成像靶点,通过在体情况下监测MPO的活性,协助炎症相关疾病的诊断。利用MPO酶学激活的原理将MPO可催化的底物同能产生影像学信号的物质以特定方法结合便可构成MPO特异性分子探针。本文将以MPO为靶点的各种成像探针及其在体应用情况进行综述。
[Abstract]:Myeloperoxidase (MPO) is an important marker of many inflammatory diseases, including atherosclerosis, vasculitis, stroke, cancer, Parkinson's disease, Alzheimer's disease, multiple sclerosis, and so on. To assist in the diagnosis of inflammatory diseases by monitoring the activity of MPO in vivo. Using the principle of MPO enzymatic activation, a specific MPO molecular probe can be constructed by combining the catalytic substrate of MPO with a substance capable of producing imaging signals in a specific way. In this paper, various imaging probes targeting MPO and their applications in vivo are reviewed.
【作者单位】：山东大学齐鲁医院放射科;复旦大学附属华山医院放射科;
【基金】：国家自然科学基金资助项目(81271633) 山东大学齐鲁医院科研基金资助项目(2016QLQN26)
【分类号】：R445

【相似文献】