可降解支架修复骨缺损的有限元模拟预测

发布时间：2018-05-05 18:27

本文选题：骨成形 + 可降解支架　；参考：《生物医学工程学杂志》2014年03期

【摘要】：针对骨组织工程支架降解问题,研究利用支架的非均匀结构来控制骨缺损修复效果的可行性。在分析了组织工程骨骼修复过程及主要影响因素的基础上,构建了骨成形控制方程、支架降解控制方程为主体的骨缺损修复预测模型,并与有限元法相结合,预测骨缺损修复过程和修复后的骨结构形态。基于以上方法,分别模拟了均匀及非均匀支架情形下的骨缺损修复效果。预测结果表明,支架结构对修复效果具有较大影响,可以利用支架的非均匀结构来控制骨缺损修复效果。
[Abstract]:In order to solve the problem of bone tissue engineering scaffold degradation, the feasibility of using the non-uniform structure of the scaffold to control the repair effect of bone defect is studied. On the basis of the analysis of the repair process and the main influencing factors of the tissue engineering skeleton, the bone formation control equation and the bone defect repair prediction model, which is the main body of the scaffold degradation control, are constructed. Combined with the finite element method, the repair process of bone defect and the bone structure after repair are predicted. Based on the above method, the repair effect of bone defect is simulated under the condition of uniform and non-uniform scaffold. The results show that the scaffold structure has a great influence on the repair effect, and the nonuniform structure of the scaffold can be used to control the repair effect of bone defect. Fruit.

【作者单位】：特种装备制造与先进加工技术教育部/浙江省重点实验室(浙江工业大学);
【基金】：国家自然科学基金资助项目(50905164,51375453) 浙江省自然科学基金资助项目(Y2090835,LY13E050017)
【分类号】：R318.08

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