葡聚糖作为新型医用敷料的应用研究与前景

发布时间：2018-05-06 00:07

本文选题：生物敷料 + 葡聚糖类　；参考：《中国组织工程研究》2017年26期

【摘要】：背景:目前市场上各种新型敷料层出不穷,并呈现多样化、多功能的发展趋势,而尚未有一种敷料能够满足人们对理想创面敷料的需求,这种理想的新敷料仍在探索中。目的:了解葡聚糖的基本生理功能、自身高分子优势以及与其他高分子、大分子结合的促愈合效果,推进葡聚糖作为新型医用敷料的研究进程。方法:利用计算机检索CNKI、Pub Med、万方医学网、维普数据库从2000年1月到2016年12月的相关文献,中文检索词为"葡聚糖,伤口敷料",英文检索词为"dressing,dextran,wound healing"。通过文献精读和泛读后得到与葡聚糖和伤口敷料相关的综述类文献以及相关研究文献31篇。结果与结论:(1)葡聚糖具有促进伤口愈合、提高免疫力的生理功能,这些生理功能是葡聚糖作为医用敷料的基础;(2)葡聚糖具有吸水性、生物可降解性、无毒性等高分子优势;(3)将葡聚糖与其他高分子、大分子结合制备的新型聚合物已通过动物实验发现具有促进伤口愈合的效果。以上几点共同说明了葡聚糖在制备新型医用敷料方面具有广阔的临床前景。
[Abstract]:Background: at present, a variety of new dressings are emerging in the market, showing a diversified and multi-functional trend, but there is not yet a dressing to meet the needs of the ideal wound dressing, this ideal new dressing is still in the process of exploration. Objective: to understand the basic physiological function of dextran, its own polymer advantages and the healing effect of combination with other macromolecules and macromolecules, and to promote the research progress of dextran as a new medical dressing. Methods: the relevant documents of CNKI Pub Med, Wanfang Medical Network and Wiper database from January 2000 to December 2016 were searched by computer. The Chinese key words were "dextran, wound dressing", and the English key word was "dressing-dextran tranwound healing". After intensive and extensive reading of the literature, 31 related literature and literature about dextran and wound dressing were obtained. Results and conclusion: dextran has the physiological functions of promoting wound healing and enhancing immunity. These physiological functions are that dextran is the basis of medical dressing.) dextran has water absorption and biodegradability. A new type of polymer, which combines dextran with other macromolecules and macromolecules, has been found to promote wound healing through animal experiments. These points show that dextran has a broad clinical prospect in the preparation of new medical dressings.
【作者单位】：中国医学科学院整形外科医院;北京博辉瑞进生物科技有限公司;
【基金】：国家高技术研究发展计划(863计划)(2015AA033602)~~
【分类号】：R318.08

【相似文献】