周围神经损伤后瓦勒氏变性及神经导管的研究与进展

发布时间：2018-05-16 23:10

本文选题：周围神经 + 髓鞘　；参考：《中国组织工程研究》2017年10期

【摘要】：背景:如何促进损伤的周围神经再生尤其是大段神经缺损是一个棘手的临床难题,亟待解决。目的:回顾近些年瓦勒氏变性机制及神经导管的发展。方法:检索PubM ed数据库,检索词为"peripheral nerve regeneration;Wallerian degeneration;nerve guidance conduits。根据纳入排除标准,选出有关瓦勒氏变性分子机制及神经修复的文献74篇进行探讨。结果与结论:研究发现大鼠SARM1和同源物果蝇d SARM在促进瓦勒氏变性中起关键作用,推断烟酰胺腺嘌呤单核苷酸/烟酰胺腺嘌呤二核苷酸比例的改变可能对SARM1的激活起一定的作用。对于延迟瓦勒氏变性到底是好是坏,目前还存在争议。周围神经损伤后短时间内抑制瓦勒氏变性并积极促进再生达到周围神经损伤及时修复是未来努力的方向。
[Abstract]:Background: how to promote the regeneration of injured peripheral nerve, especially the large segment nerve defect, is a difficult clinical problem to be solved. Objective: to review the mechanism of Vall's degeneration and the development of nerve catheter in recent years. Methods: PubM ed database was searched with the key words "peripheral nerve regeneration and Wallerian degenerate nerve guidance conduits." According to the exclusion criteria, 74 articles about the molecular mechanism of Vall's degeneration and nerve repair were selected. Results and conclusion: it was found that rat SARM1 and Drosophila melanogaster d SARM play a key role in promoting Vall degeneration. It is inferred that the change of the ratio of nicotinamide adenine mononucleotides to nicotinamide adenine dinucleotides may play a role in the activation of SARM1. Whether the delay in Vall's denaturation is good or bad is still controversial. It is the direction of future efforts to inhibit Vall's degeneration and promote regeneration to timely repair of peripheral nerve injury in a short period of time after peripheral nerve injury.
【作者单位】：解放军总医院骨科研究所北京市再生医学重点实验室全军战创伤重点实验室;
【基金】：国家自然科学基金项目(51073024;51273021) 973重点项目(2014CB542201;2012CB518106) 军队“十三五”医学专项(BWS13C029)~~
【分类号】：R318.08;R745

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