可降解聚合物血管支架结构优化设计

发布时间：2018-05-20 17:25

本文选题：可降解聚合物 + 血管支架　；参考：《力学学报》2017年06期

【摘要】：聚合物血管支架由于材料刚度较低导致其径向支撑能力相对于金属血管支架较弱,通常采用增大支架筋宽和厚度的方式来提高其径向支撑能力,但这不仅会降低支架的柔顺性能,减小血管管腔获得面积,还会增大表面覆盖率,从而增大支架内再狭窄的风险.为了设计出具有较小筋宽和厚度的聚合物血管支架,提高其径向支撑能力,本文采用一种将Kriging代理模型和有限元方法相结合的优化方法来优化支架的结构.采用Kriging代理模型建立设计目标和设计变量之间近似的函数关系,采用优化拉丁超立方抽样方法选取初始样本点,采用EI函数平衡局部和全局搜索,以便获得全局最优解.选取ART18Z聚合物支架作为算例,首先将支架的筋宽和厚度各减小0.02 mm,然后采用优化方法优化ART18Z支架的几何结构参数.数值结果表明,优化后ART18Z支架的综合服役性能得到改善,文中提出的优化方法能有效地应用于聚合物血管支架的优化设计.
[Abstract]:The radial support ability of polymer vascular stent is weaker than that of metal vascular stent due to its low material stiffness. Increasing the width and thickness of the scaffold is usually used to improve the radial support ability. However, this will not only reduce the compliance of the stent, reduce the vascular lumen area, but also increase the surface coverage, thus increasing the risk of restenosis in the stent. In order to design a polymer vascular stent with small rib width and thickness and improve its radial support ability, an optimization method combining Kriging agent model and finite element method is used to optimize the structure of the scaffold. The Kriging agent model is used to establish the approximate functional relationship between the design objective and the design variables, the initial sample points are selected by the optimal Latin hypercube sampling method, and the ei function is used to balance the local and global search in order to obtain the global optimal solution. The ART18Z polymer scaffold was selected as an example. Firstly, the width and thickness of the rib were reduced by 0.02 mm, and then the geometric parameters of the ART18Z scaffold were optimized by the optimization method. The numerical results show that the comprehensive service performance of the optimized ART18Z stent is improved, and the proposed optimization method can be effectively applied to the optimal design of polymer vascular stent.
【作者单位】：大连理工大学机械工程学院;郑州大学微纳成型技术国家级国际联合研究中心及河南省微成型重点实验室;
【基金】：国家自然科学基金项目(11502044) 中国博士后科学基金面上项目(2014M561222) 国家级微纳成型技术国际联合研究中心与河南省微成型技术重点实验室联合开放基金项目(MMT2017-03)资助
【分类号】：R318.08

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