心血管补片在先天性心脏疾病中的研究与应用前景

发布时间：2018-05-27 10:18

本文选题：心脏病 + 生物相容性材料　；参考：《中国组织工程研究》2017年10期

【摘要】：背景:组织工程心血管补片在外科手术治疗先天性心脏病的解决方案中起着决定性的作用。组织工程心血管补片构建策略灵活丰富,基础研究和临床应用范围广泛。目的:对心血管补片在先天性心脏病外科手术治疗中的应用进展以及组织工程心血管补片的构建方法进行综述。方法:采用电子检索方式检索PubM ed数据库、Medline数据库、相关期刊论文、临床试验注册资料库2001年1月至2016年12月收录的有关组织工程心血管补片分类、设计研究以及基础和临床研究的文献。以"cardiac tissue engineering,pericardium patch,stem cell,congential heart disease,congenital heart conditions,CHD"为英文检索词,以"心脏补片,血管补片,心血管补片和先天性心脏病"为中文检索词。最终纳入32篇文献进行分析。结果与结论:随着人类干细胞生物学、材料学和检测技术的进步,组织工程心血管材料有望实现标准化和产业化管理。但随之而来的问题也有很多,例如:三维血管设计策略的具体实施方法,多种种子细胞联合搭载的比例控制,临床前质控和产业化管理标准等,紧密的国际间合作能够推动整体产业健康良好地发展。
[Abstract]:Background: tissue engineering cardiovascular patch plays a decisive role in surgical treatment of congenital heart disease. Tissue engineering cardiovascular patch construction strategy is flexible, basic research and clinical application range. Objective: to review the application of cardiovascular patch in surgical treatment of congenital heart disease and the construction method of tissue engineering cardiovascular patch. Methods: PubM ed database, Chinese journal full-text database and clinical trial registration database were searched by electronic retrieval. The classification of tissue engineering cardiovascular patch was collected from January 2001 to December 2016. Design studies and literature on basic and clinical studies. The Chinese key words were "cardiac tissue engineering pericardium patchardium coronary cell congestive heart disease and congenial heart conditionsCHD" and "heart patch, vascular patch, cardiovascular patch and congenital heart disease". Finally, 32 articles were included for analysis. Results & conclusion: with the progress of human stem cell biology, materials and detection techniques, tissue engineering cardiovascular materials are expected to be standardized and industrialized management. However, there are also many problems, such as the specific implementation methods of three-dimensional vascular design strategy, the proportion control of multiple seed cells, pre-clinical quality control and industrialization management standards, etc. Close international cooperation can promote the healthy development of the industry as a whole.
【作者单位】：遵义医学院附属医院贵州省细胞工程重点实验室;遵义医学院附属医院贵州省生物治疗人才基地;中国医学科学院基础医学研究所北京协和医学院基础学院中国医学科学院组织工程研究中心干细胞新药研发及临床转化研究北京市重点实验室;
【基金】：贵州省骨髓与羊膜干细胞基础与临床研究科技创新人才团队项目(黔科合人才团队(2016)5614号) 遵义市干细胞与再生医学工程研究中心建设项目(省市科合(2014)59号)~~
【分类号】：R318.08;R654.2

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