韧带-骨支架仿生界面设计与制造方法

发布时间：2018-05-28 02:32

本文选题：韧带-骨支架 + 仿生界面　；参考：《西安交通大学学报》2014年10期

【摘要】：针对当前软质韧带支架与硬质骨组织通过机械固定进行韧带修复存在的应力集中与疲劳断裂问题,提出了具有仿生界面的韧带-骨支架设计与制造方法。研究了自然韧带-骨界面的微观结构,通过工程简化设计了具有仿生界面的韧带-骨复合支架,提出了韧带-骨支架仿生界面的分层制造方法,从材料、力学及微观结构方面对所制备的韧带-骨支架仿生界面进行了分析评价。结果表明,所提出的分层制造方法可在软质韧带纤维支架与硬质陶瓷骨支架之间精确制造出所设计的仿生界面,其在材料成分、力学性能及微观结构上呈现分区变化特性。后期通过骨支架与自体骨融合生长以及仿生界面的多组织再生,有望实现韧带纤维支架与自体骨骨道的生理愈合及可靠固定,从而为临床韧带修复提供一种新思路。
[Abstract]:Aiming at the problems of stress concentration and fatigue fracture in ligament repair by mechanical fixation of soft ligament scaffold and rigid bone tissue, a design and manufacture method of ligaments-bone scaffold with biomimetic interface was proposed. The microstructure of natural ligaments-bone interface was studied. The ligaments-bone composite scaffold with biomimetic interface was designed by engineering simplification. The laminar fabrication method of ligaments-bone scaffold bionic interface was put forward. The biomimetic interface of ligament- bone scaffold was analyzed and evaluated in mechanics and microstructure. The results show that the designed biomimetic interface can be accurately fabricated between the flexible ligament fiber scaffold and the rigid ceramic bone scaffold, and the material composition, mechanical properties and microstructure of the biomimetic interface can be changed in different zones. Through bone scaffold and autogenous bone fusion growth and multi-tissue regeneration of biomimetic interface, it is hopeful to realize the physiological healing and reliable fixation of ligament fiber scaffold and autogenous bone canal, thus providing a new idea for clinical ligament repair.
【作者单位】：西安交通大学机械制造系统工程国家重点实验室;苏黎世联邦理工学院生物力学研究所;利兹大学医学生物研究所;
【基金】：国家自然科学基金资助项目(51105298) 高等学校博士学科点专项科研基金资助项目(20110201120027) 中央高校基本科研业务费专项资金资助项目
【分类号】：R318.08

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