维生素E稳定型交联超高分子量聚乙烯在骨关节置换中的研究进展

发布时间：2018-05-28 05:45

本文选题：聚乙烯 + 生物相容性材料　；参考：《中国组织工程研究》2016年31期

【摘要】：背景:维生素E稳定型交联超高分子量聚乙烯作为最新一代的聚乙烯分子材料,近年来已被广泛应用于各类人工关节置换中,然而其磨损及因磨损产生的溶骨反应仍是影响疗效的重要因素。目的:旨在探讨和总结维生素E稳定型交联超高分子量聚乙烯的生物特性及应用进展,为指导维生素E稳定型交联超高分子量聚乙烯在临床中的开展寻求理论基础。方法:第一作者计算机检索中国知网和MEDLINE数据库。检索词为"ultra-high molecular weight polyethylene;vitamin E-stabilized;joint replacement;application"。检索语言设置为英文。结果与结论:共检索到92篇文章,根据纳入和排除标准,对文献进行筛选,最终纳入46篇。结果表明,维生素E稳定型交联超高分子量聚乙烯不仅能够进一步加强假体材料的各项理化特性,同时能够与自由基结合,提高假体材料的抗氧化率,延长假体材料的远期疗效。但仍然缺少大量临床案例及随访调查作为依据,远期临床疗效仍有待评估。
[Abstract]:Background: vitamin E stable crosslinked ultrahigh molecular weight polyethylene (UHMWPE) as the latest generation of polyethylene molecular material has been widely used in various artificial joint replacement in recent years. However, wear and osteolysis reaction due to wear are still important factors affecting curative effect. Objective: to explore and summarize the biological characteristics and application progress of vitamin E stable crosslinked ultra high molecular weight polyethylene (UHMWPE), and to seek theoretical basis for guiding the clinical application of vitamin E stabilized UHMWPE. Methods: the first author searched Chinese knowledge net and MEDLINE database by computer. The key word is "ultra-high molecular weight polyethylenevitamin E-stabilizing joint replacement application". The retrieval language is set to English. Results & conclusion: a total of 92 articles were retrieved. According to the inclusion and exclusion criteria, the literature was screened and 46 articles were included. The results showed that vitamin E stable crosslinked UHMWPE could not only enhance the physical and chemical properties of prosthesis materials, but also combine with free radicals and improve the oxidation resistance of prosthesis materials. Long-term effect of lengthening prosthesis material. However, a large number of clinical cases and follow-up investigations are still lacking, and the long-term clinical results still need to be evaluated.
【作者单位】：成都体育学院;
【基金】：国家自然科学基金(51273028)~~
【分类号】：R687.4;R318.17

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