新型交联方法在生物衍生材料中的应用进展

发布时间：2018-06-02 03:48

本文选题：生物衍生材料 + 交联方法　；参考：《中国修复重建外科杂志》2014年06期

【摘要】：目的综述新型交联方法在生物衍生材料中的应用与研究进展。方法查阅近年来国内外生物衍生材料交联方法的相关文献,并对其进行总结与分析。结果生物衍生材料的新型交联方法可划分为化学交联法、物理交联法和生物交联法三大类,其适用范围及交联性能因交联机制而异。因此,可根据材料的应用需要选择最适宜的交联方法。一系列研究结果表明,交联后的生物衍生材料可有效应用于组织修复与重建。结论使用新型交联方法制备的生物衍生材料具有优良的生物相容性和组织修复能力、更理想的机械性能和降解性能等。这些方法为材料的交联改性提供更多选择,有助于得到更适用于临床的组织工程产品。
[Abstract]:Objective to review the application and research progress of new cross-linking method in biological derivatives. Methods to review the literature about cross-linking methods of biological derivative materials in recent years, and summarize and analyze them. Results the new cross-linking methods of bio-derived materials can be divided into chemical cross-linking method, physical cross-linking method and biological cross-linking method. The scope of application and crosslinking properties vary with the crosslinking mechanism. Therefore, the most suitable crosslinking method can be selected according to the application of materials. A series of results show that the cross-linked biomaterials can be effectively used in tissue repair and reconstruction. Conclusion Bio-derived materials prepared by new cross-linking method have excellent biocompatibility and tissue repair ability, and better mechanical properties and degradation properties. These methods provide more options for cross-linking modification of materials and contribute to the development of tissue engineering products that are more suitable for clinical use.
【作者单位】：四川大学华西医院再生医学研究中心·干细胞与组织工程研究室;
【基金】：国家自然科学基金资助项目(31271058) 中国博士后科学基金资助项目(2013M531971) National Natural Science Foundation of China(31271058) Postdoctoral Science Foundation of China(2013M531971)
【分类号】：R318.08

【参考文献】