构建仿生解剖外形的个体化人工骨的新方法

发布时间：2018-06-03 18:39

本文选题：快速成形 + 三磷酸钙　；参考：《哈尔滨医科大学学报》2014年03期

【摘要】：目的研究利用微球胶联法和快速成形技术制备具备解剖结构的个体化人工骨的可行性。方法首先制备三磷酸钙微球,以兔股骨的一段作为重建模型,通过CT图像重建三维数字模型。利用反求法建立模板数据模型,再用激光固化快速成形法制备出模板实体。将三磷酸钙微球填充入模板,藻酸胶联塑形,去除模板后对个体化人工骨进行形态学观察分析。结果成功制备出三磷酸钙微球,并根据CT图像借助激光固化快速成形技术成功制备出光硬化树脂模板。将微球填充入模板并用藻酸钠水凝胶交联塑形,成功获得与兔股骨解剖外形一致的个体化人工骨。结论微球胶联法结合激光快速成形技术可以成功制备具有解剖外形结构的个体化人工骨,该方法作为间接法制备个体化生物陶瓷支架的新技术可以应用于组织工程中。
[Abstract]:Objective to study the feasibility of microsphere bonding and rapid prototyping for the preparation of individual artificial bone with anatomical structure. Methods firstly, calcium triphosphate microspheres were prepared, and a segment of rabbit femur was used as the reconstruction model, and the 3D digital model was reconstructed by CT image. The template data model was established by reverse method, and the template entity was prepared by laser solidification rapid prototyping. The calcium triphosphate microspheres were filled into the template, and the alginate gel was combined to form the bone. After removing the template, the morphology of the individual artificial bone was observed and analyzed. Results the calcium triphosphate microspheres were successfully prepared and the photohardening resin template was successfully prepared by laser curing rapid prototyping according to CT images. The microspheres were filled into the template and crosslinked with sodium alginate hydrogel to obtain the individualized artificial bone which was consistent with the anatomical shape of rabbit femur. Conclusion Microspheres combined with laser rapid prototyping can be used to fabricate individualized artificial bone with anatomical structure. This method can be used in tissue engineering as a new indirect method to fabricate individualized bioceramic scaffolds.
【作者单位】：哈尔滨医科大学附属第二医院骨科;哈尔滨医科大学附属第二医院科研实验中心;东京大学工学部再生医工学研究室;
【基金】：黑龙江省自然科学基金资助项目(LC201020) 黑龙江省卫生厅科研课题(2010-094) 哈尔滨市科技创新人才专项基金(2011RFLYSO31)
【分类号】：R318.1

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