基于纳米纤维素的三维组织工程支架多孔结构的调控与表征

发布时间：2018-06-09 03:55

本文选题：复合材料 + 纳米纤维素　；参考：《材料研究学报》2014年10期

【摘要】：本文将纳米纤维素(CNFs)与聚乙烯醇(PVA)混合,采用冷冻干燥方法制备了纳米纤维素三维多孔组织工程支架。探讨CNFs悬浮液浓度、PVA的相对分子质量、CNFs与PVA的质量比以及冷冻温度对支架孔隙率、孔径分布以及机械性能的影响。结果表明:CNFs/高相对分子质量PVA支架具有梯度分布、内部连通的孔结构,PVA形成大孔的孔壁,直径100-200 nm的CNFs束则在孔壁上桥接为类似于细胞外基质(ECM)中胶原骨架的网状结构;CNFs浓度为0.5%、CNFs与PVA的质量比为1∶2、冷冻温度为-80℃时,支架内部微丝丰富且网络结构较好;支架力学强度主要由PVA提供,支架的压缩模量随PVA用量的增加而增大,压缩模量在kPa数量级,与软骨组织的弹性模量相当,可通过改变PVA的添加量调节支架材料的力学性能。
[Abstract]:In this paper, Nanosolids (CNFs) and polyvinyl alcohol (PVA) were mixed and the three-dimensional porous scaffolds of Nanosolids were prepared by freeze-drying. The concentration of CNFs suspension, the relative molecular mass of PVA, the mass ratio of CNFs to PVA and the effect of freezing temperature on the porosity, pore size distribution and mechanical properties of the scaffolds were investigated. The CNFs/ high relative molecular mass PVA stent has a gradient distribution, the inner connected pore structure, the PVA formation of the pore wall of the large hole, and the CNFs beam of 100-200 nm in diameter bridge the mesh structure of the collagen skeleton similar to the extracellular matrix (ECM) on the hole wall; the CNFs concentration is 0.5%, the mass ratio of CNFs to PVA is 1: 2, and the freezing temperature is -80 C. The microfilament is rich and the network structure is good; the mechanical strength of the scaffold is mainly provided by PVA. The compression modulus of the scaffold increases with the increase of the amount of PVA. The compression modulus is in the kPa order of magnitude, which is equivalent to the elastic modulus of the cartilage tissue. It can adjust the force properties of the scaffold material by changing the amount of PVA.
【作者单位】：华南理工大学制浆造纸国家重点实验室;
【基金】：国家重点基础研究发展计划2010CB732206资助项目~~
【分类号】：R318.08

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