功能型骨组织工程支架修复结核性骨缺损

发布时间：2018-06-18 14:40

  本文选题：结核 + 骨关节　； 参考：《中国组织工程研究》2016年30期

【摘要】：背景:随着抗结核功能型骨组织工程支架研究的深入,结核性骨缺损修复成为当前研究热点之一。目的:评价抗结核功能型骨组织工程支架的制备、药物缓释性能和成骨性能。方法:应用计算机检索Pub Med数据库、相关期刊论文、万方数据库中,相关功能型骨组织工程支架修复结核性骨缺损的文章,中文检索词为"骨组织工程支架,结核,骨缺损",英文检索词为"Bone tissue engineering scaffold,Tuberculosis,Bone defect"。结果与结论:抗结核功能型骨组织工程支架具有较好的药物缓释性能、组织相容性、成骨性能及抗结核杆菌性能,能长时间稳定释放药物,增强局部应用抗结核药的效果,解决临床上结核性骨缺损修复困难易复发的难题。目前,研制的抗结核性骨组织工程支架还未达到临床需求。首先,针对结核分枝杆菌的多药物联合治疗常需3或4种抗结核药物的联合使用,而目前抗结核性骨组织工程支架只能达到联合2种药物;其次,抗结核治疗疗程常需6-12个月,现有的抗结核性骨组织工程支架药物释放时还不能满足该需求;制备抗结核性骨组织工程支架材料的文献居多,但应用此种材料在结核动物模型进行的验证实验缺失。关键词:
[Abstract]:Background: with the development of anti-tuberculosis functional bone tissue engineering scaffolds, the repair of tuberculous bone defects has become one of the hotspots. Objective: to evaluate the preparation, drug release and osteogenesis of anti-tuberculosis functional bone tissue engineering scaffolds. Methods: the relevant functional bone tissue engineering scaffolds for repairing tuberculous bone defects were searched by computer in Pub Med database, full text database of Chinese periodicals and Wanfang database. The Chinese key words were "bone tissue engineering scaffold, tuberculosis, tuberculosis". Bone tissue engineering scaffold was used as bone defect. Results and conclusion: the anti-tuberculosis functional bone tissue engineering scaffold has good drug release ability, histocompatibility, osteogenic property and anti-tuberculous bacilli performance. It can release drugs stably for a long time and enhance the effect of local application of anti-tuberculosis drugs. To solve the clinical tuberculous bone defect repair difficulties and recurrence problems. At present, the anti-tuberculous bone tissue engineering scaffold has not met the clinical requirements. First, the multi-drug combination therapy for Mycobacterium tuberculosis often requires three or four anti-tuberculosis drugs, but at present, the anti-tuberculous bone tissue engineering stent can only combine two drugs; secondly, the course of anti-tuberculosis treatment often takes 6-12 months. The current anti-tuberculous bone tissue engineering stents drug release can not meet this demand; the preparation of anti-tuberculous bone tissue engineering scaffold materials literature is the majority, but the application of this material in the animal model of tuberculosis validation is missing. Keywords:
【作者单位】： 庆阳市人民医院骨二科;甘肃省第二人民医院骨科;解放军兰州军区兰州总医院全军骨科中心;
【基金】：国家自然科学基金(81371983):多孔β-TCP负载聚乳酸羟基乙酸共聚物抗结核药物缓释微球的构建及其抗结核成骨作用研究~~
【分类号】：R68;R318.08
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本文编号：2035835