d-f配合物杂化的金纳米笼的合成及其在多模态成像与光热治疗中的研究

发布时间：2018-07-04 21:47

本文选题：d-f聚合物 + 金纳米笼　；参考：《上海师范大学》2017年硕士论文

【摘要】：传统的d-f配合物纳米粒子由于良好的光学-磁学性质,在光学成像,磁共振成像,磁共振成像与光动力学治疗等方面得到了广泛的应用。但由于d-f配合物纳米粒子的吸收主要在紫外-可见光区,限制了其在活体层次的应用。金纳米笼是一类出色的光热转换材料,对近红外光有很强的吸收能力,可以用于光声成像与光热治疗等。本文提出了一种结合的策略——将铱-镝配位聚合物包裹在金纳米笼表面,得到了d-f配合物杂化的金纳米笼(AuNC@CPs),并对AuNC@CPs的性质进行了研究。本文的主要内容包括:(1)通过多元醇还原的方法合成了银纳米立方块,并以银纳米立方块为原料,合成了一系列不同的金纳米笼,并对金纳米笼形成机理及其光谱性质进行了讨论;(2)以局部表面等离子体共振(LSPR)峰在697 nm的金纳米笼为模板,用HS-PEG-NH2进行表面修饰,最后采用透析法将配位聚合物与金纳米笼进行杂化,得到具有核壳结构的AuNC@CPs,并且产物的LSPR峰红移到了825 nm。我们对AuNC@CPs的合成机理与方法的普适性进行了讨论;(3)利用AuNC@CPs的近红外吸收性质,磷光发射性质与磁性,在溶液层次进行了AuNC@CPs的光热,光动力学,光声成像与磁共振成像研究;(4)在细胞与活体层次,对AuNC@CPs的光学成像,光热治疗,光声成像与磁共振成像进行了研究。
[Abstract]:The traditional d-f complex nanoparticles have been widely used in optical imaging, magnetic resonance imaging and photodynamic therapy due to their good optical and magnetic properties. However, the absorption of d-f complex nanoparticles is mainly in the UV-Vis region, which limits their application at the in vivo level. Gold nanocage is a kind of excellent photothermal conversion material. It has strong absorption ability to near infrared light and can be used in photoacoustic imaging and photothermal therapy. In this paper, a binding strategy is proposed, in which iridium dysprosium coordination polymer is encapsulated on the surface of gold nanospheres, and the au cages (AuNCfollow-up CPs) hybrid with d-f complexes are obtained, and the properties of AuNCfollow-up CPs are studied. The main contents of this paper are as follows: (1) Silver nanorods were synthesized by polyol reduction, and a series of different gold nanometers were synthesized from silver nanorods. The formation mechanism and spectral properties of gold nanorages were discussed. (2) the gold nanocages with local surface plasmon resonance (LSPR) peak at 697 nm were used as templates and HS-PEG-NH2 was used to modify the surface. Finally, the coordination polymer was hybridized with gold nanocapron by dialysis method, and AuNCBP with core-shell structure was obtained, and the LSPR peak of the product was shifted to 825 nm. We have discussed the synthesis mechanism and the universality of the method of AuNC@ CPs. (3) the photothermal and photodynamic properties of AuNCneuroCPs have been carried out at the solution level using the near infrared absorption, phosphorescence and magnetism of AuNC@ CPs. (4) the optical imaging, photothermal therapy, photoacoustic imaging and magnetic resonance imaging of AuNCCCPs were studied at the cellular and in vivo levels.
【学位授予单位】：上海师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R318;O641.4

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