具有X-射线自显影功能的碘代聚氨酯栓塞剂材料的研究

发布时间：2018-09-03 17:21

【摘要】：设计合成四碘代双酚A(IBPA)作为扩链剂,以聚丁二酸丁二醇酯(PBS-OH)为软段、异佛尔酮二异氰酸酯(IPDI)和IBPA为硬段,通过偶联反应获得一种新型X-射线聚氨酯显影材料.红外光谱和核磁共振氢谱确定所合成碘代聚氨酯(I-PUs)的结构与组成,并用示差扫描量热法,热重分析,X-射线衍射仪和临床X-射线仪评价不同IBPA含量的碘代聚氨酯的热性能、结晶性和显影效果.结果表明,碘代扩链剂IBPA较高含量的引入对聚合物的热稳定性有一定的影响,并促使聚氨酯由结晶态向非晶态转变.引入IBPA对聚氨酯的显影效果有很好的促进增强作用,聚氨酯材料及微球均具有较好的X光显影效果.噻唑蓝比色法(MTT)评价细胞毒性证实制备的较高碘含量的聚氨酯材料均无细胞毒性,是一种很好的血管栓塞剂材料.
[Abstract]:A new type of X-ray polyurethane was synthesized by coupling reaction with tetraiodobisphenol A (IBPA) as chain extender, poly (butylene succinate) (PBS-OH) as soft segment and isophorone diisocyanate (IPDI) and IBPA as hard segments. The structure and composition of the synthesized iodized polyurethane (I-PUs) were determined by IR and NMR. The thermal properties of iodized polyurethane with different IBPA content were evaluated by thermogravimetry, X-ray diffractometer and clinical X- ray spectrometer. Crystallization and development effect. The results showed that the introduction of iodine chain extender IBPA had a certain effect on the thermal stability of the polymer and promoted the transition of polyurethane from crystalline to amorphous. The introduction of IBPA can promote the development of polyurethane. Polyurethane materials and microspheres have good X-ray development effect. Thiazolyl blue colorimetric assay (MTT) was used to evaluate the cytotoxicity of polyurethane with high iodine content.
【作者单位】：大连理工大学材料科学与工程学院;大连理工大学汽车工程学院;大连理工大学精细化工国家重点实验室大连干细胞和组织工程研究中心;大连友谊医院放射科;
【基金】：国家自然科学基金(基金号31000427) 中央高校基本科研业务费(项目号DUT12JB09)资助项目
【分类号】：R318.08

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