生物细胞三维打印技术与材料研究进展

发布时间：2018-09-19 07:31

【摘要】：生物细胞三维(3D)打印是一种新型的制造技术,通过该技术可以将细胞以及细胞支撑材料打印成复杂的具有3D结构与功能的组织。与其他3D打印技术相比,生物细胞3D打印需要对打印过程以及打印材料的生物环境进行研究。针对生物细胞3D打印的特点,本文主要讨论了生物细胞3D打印技术的发展现状,重点从打印技术与打印材料两个方面展开介绍。其中,针对现有打印技术,本文重点介绍了喷墨法、挤出沉积法、光固化成型法以及激光辅助法的精度、制备过程、材料要求以及对细胞状态影响,并在此基础上比较了各自的优势和局限性;针对常用的打印材料,本文重点介绍并对比了其交联方式、生物相容性以及应用场合等。生物细胞3D打印技术目前仍主要在实验室发展阶段,对现阶段生物3D打印技术原理与发展进行回顾总结不仅有助于思考如何将这一技术尽快投入实用,也有助于更好地规划生物3D打印的未来发展方向。
[Abstract]:Three-dimensional (3D) printing of biological cells is a new manufacturing technology, through which cells and their supporting materials can be printed into complex tissue with 3D structure and function. Compared with other 3D printing techniques, biological cell 3D printing needs to study the printing process and the biological environment of printing materials. According to the characteristics of biological cell 3D printing, this paper mainly discusses the development of biological cell 3D printing technology, focusing on printing technology and printing materials. Aiming at the existing printing technology, this paper mainly introduces the precision, preparation process, material requirement and effect on cell state of inkjet method, extrusion deposition method, light curing method and laser assisted method. On the basis of this, the advantages and limitations are compared, and the common printing materials are introduced and compared in this paper, including their crosslinking methods, biocompatibility and applications. The biological cell 3D printing technology is still mainly in the laboratory development stage at present. It is not only helpful to think about how to put this technology into practice as soon as possible, but also to review and summarize the principle and development of biological 3D printing technology at this stage. It also helps to better plan the future direction of biological 3D printing.
【作者单位】：安徽医科大学生命科学学院生物医学工程系;
【基金】：国家自然科学基金资助项目(61603002) 安徽医科大学博士科研资助项目
【分类号】：R318.08

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