医用纤维蛋白粘合剂的研究进展
发布时间:2018-10-08 12:10
【摘要】:目的:了解纤维蛋白粘合剂的研究进展。方法:查阅近年来国内、外相关文献,对纤维蛋白粘合剂的作用机制、临床应用、新的研究方向、存在问题的研究进行归纳和总结。结果:纤维蛋白粘合剂通过与机体凝血系统相互作用产生凝血效果,黏附于创面发挥物理止血作用,被用于骨科、心胸外科、肝外科、眼科、乳腺外科、脑/神经外科等外科手术,喷洒创面使组织黏附并止血,其新的研究方向为作为缓释系统和支架材料。存在的问题包括来源污染、变态过敏反应等安全性问题,以及降解快、强度低等局限性。结论:医用纤维蛋白粘合剂因其良好的生物相容性、无毒性被广泛应用在临床手术及新型给药系统中,其未来研究应增加临床安全性并克服存在的缺陷。
[Abstract]:Objective: to understand the research progress of fibrin binder. Methods: the mechanism, clinical application, new research direction and existing problems of fibrin binder were summarized and summarized. Results: fibrin binder was used in orthopedics, cardiothoracic surgery, liver surgery, ophthalmology, mammary surgery, which produced coagulation effect by interacting with blood coagulation system. In brain / neurosurgery, sprayed wounds make tissue adhesion and hemostasis. The new research direction is to be used as a sustained-release system and scaffold material. Problems include source contamination, safety problems such as allergy, and limitations such as fast degradation and low strength. Conclusion: medical fibrin binder is widely used in clinical surgery and new drug delivery system because of its good biocompatibility and nontoxicity. Its future research should increase clinical safety and overcome the defects.
【作者单位】: 广州军区武汉总医院药剂科;湖北中医药大学药学院;
【分类号】:R318.08
本文编号:2256698
[Abstract]:Objective: to understand the research progress of fibrin binder. Methods: the mechanism, clinical application, new research direction and existing problems of fibrin binder were summarized and summarized. Results: fibrin binder was used in orthopedics, cardiothoracic surgery, liver surgery, ophthalmology, mammary surgery, which produced coagulation effect by interacting with blood coagulation system. In brain / neurosurgery, sprayed wounds make tissue adhesion and hemostasis. The new research direction is to be used as a sustained-release system and scaffold material. Problems include source contamination, safety problems such as allergy, and limitations such as fast degradation and low strength. Conclusion: medical fibrin binder is widely used in clinical surgery and new drug delivery system because of its good biocompatibility and nontoxicity. Its future research should increase clinical safety and overcome the defects.
【作者单位】: 广州军区武汉总医院药剂科;湖北中医药大学药学院;
【分类号】:R318.08
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