冠脉支架联接体波形对血管损伤与再狭窄的影响

发布时间：2018-10-12 14:46

【摘要】：针对冠脉支架植入术后的血管内再狭窄问题,建立了冠脉支架介入耦合系统的力学模型,研究了支架在血管内压握和扩张过程中的变形机理,探索了支架介入对血管损伤的力学原因。分析了N型、S型和C型冠脉支架的体内扩张性能,研究了支架联接体的几何结构对血管损伤与再狭窄的影响机理。理论研究表明:由于支架与血管的柔顺性失配,冠脉内膜在支架支撑体顶点附近存在较高的应力梯度,而且在相邻支撑体之间存在明显的内膜组织下垂。N型和S型支架介入引起的血管壁面应力梯度较大,内膜组织下垂显著,易于引起血管损伤形成内膜增生,C型支架介入引起的血管壁面应力分布相对均匀,内膜组织下垂较小,有利于减小血管损伤、降低血管的再狭窄程度。
[Abstract]:Aiming at the problem of restenosis after coronary stent implantation, a mechanical model of coronary stent interventional coupling system was established, and the deformation mechanism of stent during intravascular pressure grip and dilation was studied. The mechanical causes of vascular injury caused by stent intervention were explored. The in vivo dilation properties of N, S and C types of coronary stents were analyzed, and the influence of the geometry of stent junctions on vascular injury and restenosis was studied. The theoretical study shows that there is a high stress gradient near the top of the stent support due to the mismatch between the stent and the blood vessel. In addition, there was obvious prolapse of intimal tissue between adjacent supports. The stress gradient of vascular wall caused by N type and S type stent was larger, and the prolapse of intimal tissue was significant. It is easy to cause vascular injury to form intimal hyperplasia. The stress distribution of vascular wall induced by C-type stent is relatively uniform and the intimal tissue droop is smaller which is helpful to reduce vascular injury and reduce the degree of restenosis.
【作者单位】：哈尔滨工程大学机电工程学院;内蒙古工业大学机械工程学院;
【基金】：国家自然科学基金资助项目(81160186) 黑龙江省自然科学基金资助项目(E2015026)
【分类号】：R541.4;R318.08

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