多形态羟基磷灰石粉体、涂层的制备及表征
发布时间：2018-11-16 19:41
【摘要】：羟基磷灰石(HAP)具有良好的生物活性和生物相容性,是人类的牙齿和骨骼的主要无机矿物组成,在生物材料中占有重要的地位。近年来科技工作者已经合成了多种形态的HAP材料,例如：HAP非晶材料,HAP微球材料,HAP介孔材料,HAP晶须材料,HAP纤维材料等。由于临床上需要大量的人体硬组织替代材料,及人体植入体,而植入体与人体组织物理化学属性并不相同,需要在植入体的外面涂覆一层生物相容性好的HAP材料,目前常见的植入体材料包括：钛基合金、不锈钢、生物陶瓷等。人们龋病的常见性和多发性引起人们的重视,对牙釉质进行原位仿生再矿化是当前研究的热点内容。 本文分别采用化学沉淀法、模拟体液法、共沉淀法、明胶凝胶法制备了普通羟基磷灰石粉体、磁性羟基磷灰石粉体、板条状氟羟基磷灰石粉体。以硫酸亚铁为添加剂,与HAP共沉淀,可以制备出磁性羟基磷灰石,晶粒细小分散性很好,有作为靶向载药材料的潜力。设计了一种新的方法来制备羟基磷灰石微球,利用在化学沉淀法中制备的HAP粉体制备了一定pH值的悬浊液,通过调节pH值制备了HAP中空微球,HAP中空有核微球,HAP实心微球。 研究了硬脂酸铝、十六胺、十二烷基硫酸钠和山梨醇对羟基磷灰石晶体生长的影响,反应原料为氯化钙和磷酸氢二钠,其反应初始m(Ca)/m(P)为5：3,按照不同浓度加入外加剂,研究在多种介质下HAP颗粒的生长,并对晶粒进行了表征。 采用高能球磨法,以分析纯的Ti粉和AI粉为原料,制备了金属间化合物Ti3Al,并以在模拟体液中制备的HAP粉体为基体,Ti3Al为第二相,制备了Ti3Al/HAP复合材料,烧结温度分别为1000℃、1050℃和1100℃,并对其进行力学性能检测.力学测试结果显示Ti3Al/HAP复合材料的力学性能并没有显著提高,抗弯强度均比纯HAP陶瓷低,而烧结温度为1100℃,Ti3Al掺入量为1%的试样断裂韧性值最高。 分别在硅片、Ti3Al/HAP复合材料和牙切片上进行了涂层制备。研究结果显示通过电泳沉积法可以在硅片上制备出HAP的涂层,涂层的晶粒生长复合台阶式生长,每当台阶沿着晶面扫过一次,则晶体就长大了一层。以螯合剂EDTA-2Na为媒介,可分别在Ti3Al/HAP复合材料和牙釉质的表面制备出钙磷矿物涂层,涂层由六方棱柱状晶体组成,适当延长矿化时间和矿化温度,制备的涂层晶粒垂直于基底材料平行排列。采用酸性糊剂法可以在牙釉质的表面制备出一层致密的由细小晶粒组成的涂层,在一定pH值范围内,该涂层与酸性糊剂的pH值大小无关。
[Abstract]:Hydroxyapatite (HAP) has good bioactivity and biocompatibility. It is the main inorganic mineral composition of human teeth and bone and plays an important role in biomaterials. In recent years, many kinds of HAP materials have been synthesized, such as HAP amorphous material, HAP microsphere material, HAP mesoporous material, HAP whisker material, HAP fiber material and so on. Because a large number of human hard tissue substitute materials and human implants are needed clinically, and the physical and chemical properties of implants and human tissues are not the same, it is necessary to coat the implant with a layer of biocompatible HAP material. The commonly used implant materials include titanium alloy, stainless steel, bioceramics and so on. People pay more attention to the commonness and frequency of dental caries, and in situ biomimetic mineralization of tooth enamel is a hot topic. In this paper, common hydroxyapatite powder, magnetic hydroxyapatite powder and strip fluorohydroxyapatite powder were prepared by chemical precipitation method, simulated body fluid method, co-precipitation method and gelatin gel method. Magnetic hydroxyapatite can be prepared by co-precipitation of ferrous sulfate with HAP. The fine and dispersible grains have the potential to be used as targeted drug loading materials. A new method was designed to prepare hydroxyapatite microspheres. HAP powders prepared by chemical precipitation method were used to prepare suspensions with certain pH value. HAP hollow microspheres, HAP hollow nucleated microspheres and HAP solid microspheres were prepared by adjusting pH value. The effects of aluminum stearate, hexadecylamine, sodium dodecyl sulfate and sorbitol on the growth of hydroxyapatite crystals were studied. The raw materials of the reaction were calcium chloride and disodium hydrogen phosphate. The initial m (Ca) / m (P) ratio of the reaction was 5: 3. The growth of HAP particles in a variety of media was studied according to the addition of additives at different concentrations, and the grain size was characterized. The intermetallic compound Ti3Al, was prepared by high energy ball milling with pure Ti powder and AI powder as raw material. The Ti3Al/HAP composite was prepared by using HAP powder prepared in simulated body fluid as matrix and Ti3Al as the second phase. The sintering temperature is 1000 鈩，
本文编号：2336460
[Abstract]:Hydroxyapatite (HAP) has good bioactivity and biocompatibility. It is the main inorganic mineral composition of human teeth and bone and plays an important role in biomaterials. In recent years, many kinds of HAP materials have been synthesized, such as HAP amorphous material, HAP microsphere material, HAP mesoporous material, HAP whisker material, HAP fiber material and so on. Because a large number of human hard tissue substitute materials and human implants are needed clinically, and the physical and chemical properties of implants and human tissues are not the same, it is necessary to coat the implant with a layer of biocompatible HAP material. The commonly used implant materials include titanium alloy, stainless steel, bioceramics and so on. People pay more attention to the commonness and frequency of dental caries, and in situ biomimetic mineralization of tooth enamel is a hot topic. In this paper, common hydroxyapatite powder, magnetic hydroxyapatite powder and strip fluorohydroxyapatite powder were prepared by chemical precipitation method, simulated body fluid method, co-precipitation method and gelatin gel method. Magnetic hydroxyapatite can be prepared by co-precipitation of ferrous sulfate with HAP. The fine and dispersible grains have the potential to be used as targeted drug loading materials. A new method was designed to prepare hydroxyapatite microspheres. HAP powders prepared by chemical precipitation method were used to prepare suspensions with certain pH value. HAP hollow microspheres, HAP hollow nucleated microspheres and HAP solid microspheres were prepared by adjusting pH value. The effects of aluminum stearate, hexadecylamine, sodium dodecyl sulfate and sorbitol on the growth of hydroxyapatite crystals were studied. The raw materials of the reaction were calcium chloride and disodium hydrogen phosphate. The initial m (Ca) / m (P) ratio of the reaction was 5: 3. The growth of HAP particles in a variety of media was studied according to the addition of additives at different concentrations, and the grain size was characterized. The intermetallic compound Ti3Al, was prepared by high energy ball milling with pure Ti powder and AI powder as raw material. The Ti3Al/HAP composite was prepared by using HAP powder prepared in simulated body fluid as matrix and Ti3Al as the second phase. The sintering temperature is 1000 鈩，
本文编号：2336460
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