超临界二氧化碳相转化技术制备组织工程支架研究进展

发布时间：2018-11-19 21:24

【摘要】：组织工程支架是组织工程研究的关键要素之一。然而,传统制备方法存在操作条件复杂或有机溶剂残留量高等问题。本文基于超临界二氧化碳相转化技术操作条件温和、可以将相分离与干燥过程合二为一、有效地去除有机溶剂等优点,简要介绍了超临界二氧化碳相转化技术中应用的组织工程支架材料,具体阐述了制备出具有致密无孔结构、孔洞结构以及三维纳米纤维结构的组织工程支架的研究进展。随后对其目前存在的不足,如该项技术缺少系统的理论研究、部分制备出的支架不利于传质、负载生长因子和细胞粘附等问题提出了可能的解决方案。最后对超临界二氧化碳相转化技术制备具有类似细胞外基质结构和功能、孔洞相互贯通、微观粗糙纳米纤维表面的组织工程支架进行了展望。
[Abstract]:Tissue engineering scaffold is one of the key elements of tissue engineering research. However, the traditional preparation methods have some problems, such as complex operating conditions or high residual organic solvents. Based on the mild operating conditions of supercritical carbon dioxide phase conversion technology, the process of phase separation and drying can be combined, and organic solvents can be effectively removed. The tissue engineering scaffolds used in supercritical carbon dioxide phase conversion technology are briefly introduced. The progress in the preparation of tissue engineering scaffolds with dense porous structure, pore structure and three-dimensional nanofiber structure is described in detail. Then some possible solutions to the problems such as the lack of systematic theoretical research on the technology the unfavorable mass transfer the load growth factor and cell adhesion were put forward. Finally, the prospect of tissue engineering scaffolds with similar extracellular matrix structure and function, interpenetrating pores and rough surface of nanofibers by supercritical carbon dioxide phase transformation technology was discussed.
【作者单位】：华侨大学化工学院;华侨大学生物材料与组织工程研究所;
【基金】：国家自然科学基金(31170939,51103049,81171471) 福建省科技计划(2013Y2002)项目
【分类号】：R318.08

【参考文献】