数值模拟人内耳半规管膜迷路的机械压痕实验

发布时间：2018-11-20 10:57

【摘要】：该实验数值模拟机械压痕实验,研究机械压痕激励下人半规管膜迷路壶腹嵴顶的位移响应,探求半规管结构和平衡机理的关系。基于文献实验结果数据,建立人半规管膜迷路的三维弹性流体动力学模型,采用液固耦合方法数值模拟机械压痕实验过程。研究结果表明:低频正弦压痕载荷时(10/Hz),半规管整合激励产生的嵴顶位移响应与压痕峰值线性相关,相位相同。低频范围内的正弦压痕载荷,频率越低,水平半规管嵴顶位移峰值衰减速度越快,衰减比例大,趋于稳定时间越长。该实验建立了有效的半规管膜迷路液固耦合模型,描述了机械压痕激励与旋转激励的定量关系,为深入研究前庭力学及理解平衡机理奠定一定的基础。
[Abstract]:The mechanical indentation experiment was simulated numerically to study the displacement response of the labyrinth crest of the human semicircular canal membrane under the mechanical indentation excitation and to explore the relationship between the structure of the semicircular canal and the equilibrium mechanism. Based on the experimental data in literature, a three-dimensional elastohydrodynamic model of human semicircular canal membrane labyrinth was established, and the mechanical indentation process was numerically simulated by liquid-solid coupling method. The results show that under low frequency sinusoidal indentation loading (10/Hz), the crest displacement response induced by semicircular canal integration excitation is linearly correlated with the peak indentation peak, and the phase is the same. The lower the frequency of sinusoidal indentation in the low frequency range, the faster the peak displacement of horizontal semicircular canal crest becomes, the larger the attenuation ratio is, and the longer the stabilization time is. In this experiment, an effective liquid-solid coupling model of semicircular canal membrane labyrinth was established, and the quantitative relationship between mechanical indentation excitation and rotational excitation was described, which laid a foundation for further study of vestibular mechanics and understanding of equilibrium mechanism.
【作者单位】：大连理工大学工业装备结构分析国家重点实验室;大连医科大学第二临床学院耳鼻咽喉科;
【基金】：国家自然科学基金项目(11072055,10902022,11032008) 辽宁省教育厅资助科研项目(L2012323)
【分类号】：R318.01

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