一种基于动物实验多功能撞击仪的研制及应用
发布时间：2018-11-20 10:42
【摘要】：背景:目前有文献报道了一些用来研究创伤的仪器设备,但是鉴于这些设备自身适用范围有限,不利于创伤动物模型的建立。目的:研制一种多功能动物撞击系统并评估其初步使用效果,为动物实验创伤建模及基础研究提供支撑。方法:多功能动物撞击系统基于储能换能装置、简便式多功能撞击装置、撞击参数测量装置等三大部件的原理设计,并对其有效性和稳定性检验。采用撞击仪预设定不同撞击参数(200,300,400,500 k Pa)并选择5 cm2撞击头对大鼠胸、腹部不同部位器官实施闭合撞击实验并立即记录撞击力数据。各部位不同撞击参数下随机选择3只大鼠实行撞击操作,随后处死大鼠以解剖观察。结果与结论:(1)成功地研制出该多功能撞击仪,其撞击应力峰值连续可调节且量程在0-200 kg,压缩和挤压应力连续可调节且量程在0-100 kg;(2)动物实验表明仪器能够造成大鼠肺、肝、脾等器官不同程度的组织损伤,验证了该仪器具有良好的有效性(P0.05)和可重复性(P0.05);(3)结果说明,撞击仪操作简单,撞击方式多样,撞击参数可被实时记录;经过调试和动物实验,效果显著且性能稳定,可对不同实验动物形成不同强度和方式的创伤。适用于撞击伤的建模和有关基础研究。
[Abstract]:Background: some instruments used to study trauma have been reported, but due to their limited scope of application, it is not conducive to the establishment of animal models of trauma. Aim: to develop a multifunctional animal impact system and evaluate its preliminary application effect, and provide support for animal experimental trauma modeling and basic research. Methods: the multifunctional animal impact system was designed based on the principle of energy transfer device, simple multi-function impact device and impact parameter measuring device, and its validity and stability were tested. Different impact parameters (200300400500 k Pa) were pre-set by impactor (200300400500 k Pa) and 5 cm2 impact head was selected to conduct closed impact test on different parts of the chest and abdomen of rats and to record the impact force data immediately. Under different impact parameters, 3 rats were randomly selected for impact operation, and then killed for anatomic observation. Results and conclusions: (1) the multifunctional impactor has been successfully developed. The impact stress peak value is continuously adjustable, the range is 0-200 kg, compression, the extrusion stress is continuously adjustable and the measuring range is 0-100 kg;. (2) Animal experiments show that the instrument can cause lung, liver, spleen and other organs of the rats to different degrees of tissue damage, verified that the instrument has a good effectiveness (P0.05) and repeatability (P0.05); (3) the results show that the impact instrument is simple in operation, various in impact mode, and the impact parameters can be recorded in real time. After debugging and animal experiments, the effect is remarkable and the performance is stable, and the trauma of different intensity and mode can be caused to different experimental animals. Applicable to impact injury modeling and related basic research.
【作者单位】： 解放军成都军区总医院全军普外中心;
【基金】：国家自然科学基金(81001695) 四川省科技厅应用基础研究课题(2013JY0046)~~
【分类号】：R318.6
[Abstract]:Background: some instruments used to study trauma have been reported, but due to their limited scope of application, it is not conducive to the establishment of animal models of trauma. Aim: to develop a multifunctional animal impact system and evaluate its preliminary application effect, and provide support for animal experimental trauma modeling and basic research. Methods: the multifunctional animal impact system was designed based on the principle of energy transfer device, simple multi-function impact device and impact parameter measuring device, and its validity and stability were tested. Different impact parameters (200300400500 k Pa) were pre-set by impactor (200300400500 k Pa) and 5 cm2 impact head was selected to conduct closed impact test on different parts of the chest and abdomen of rats and to record the impact force data immediately. Under different impact parameters, 3 rats were randomly selected for impact operation, and then killed for anatomic observation. Results and conclusions: (1) the multifunctional impactor has been successfully developed. The impact stress peak value is continuously adjustable, the range is 0-200 kg, compression, the extrusion stress is continuously adjustable and the measuring range is 0-100 kg;. (2) Animal experiments show that the instrument can cause lung, liver, spleen and other organs of the rats to different degrees of tissue damage, verified that the instrument has a good effectiveness (P0.05) and repeatability (P0.05); (3) the results show that the impact instrument is simple in operation, various in impact mode, and the impact parameters can be recorded in real time. After debugging and animal experiments, the effect is remarkable and the performance is stable, and the trauma of different intensity and mode can be caused to different experimental animals. Applicable to impact injury modeling and related basic research.
【作者单位】： 解放军成都军区总医院全军普外中心;
【基金】：国家自然科学基金(81001695) 四川省科技厅应用基础研究课题(2013JY0046)~~
【分类号】：R318.6
【参考文献】
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1 符锋;赵明亮;李晓红;陈，
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