一种用于小血流速度测量的优化多普勒谱域光学相干层析术

发布时间：2018-11-22 08:59

【摘要】：提出一种能够有效提高组织中小血流成像质量的优化多普勒光学相干层析术(DOCT)。该方法通过利用谱域光学相干层析术(SDOCT)在同一横向位置对相邻和隔行A扫相位差求平均的方法来实现。介绍了该方法的理论原理,并且通过血管模拟实验验证了其可行性。在模拟实验中,通过改变脂肪溶液在毛细玻璃管中的流速,利用传统相位方法和本文提出的方法分别对速度进行测量,然后分别计算速度的平均标准差并进行比较。对老鼠耳朵的血流进行活体测量,再分别利用两种方法进行多普勒速度图像的重构。实验结果证明,在小血流速度测量方面,本文提出的方法能够在不增加相邻A扫时间间隔的情况下,有效地抑制由于系统相位不稳定而引起的相位噪声,从而提高血流速度图像的信噪比和测量精度。
[Abstract]:An optimized Doppler Optical coherence Tomography (DOCT).) is proposed to improve the imaging quality of tissue small and medium blood flow effectively. This method is realized by using spectral domain optical coherence tomography (SDOCT) to average the phase difference between adjacent and interlaced A-scan at the same transverse position. The theory and principle of the method are introduced, and the feasibility of the method is verified by blood vessel simulation experiment. In the simulation experiment, by changing the flow rate of fat solution in the capillary glass tube, the velocity is measured by using the traditional phase method and the method proposed in this paper, and then the average standard deviation of the velocity is calculated and compared. The blood flow of mouse ear was measured in vivo, and the Doppler velocity images were reconstructed by two methods. The experimental results show that the proposed method can effectively suppress the phase noise caused by the phase instability of the system without increasing the adjacent A-scan time interval in the measurement of small blood flow velocity. In order to improve the signal-to-noise ratio and measurement accuracy of blood flow velocity image.
【作者单位】：南京理工大学电子工程与光电技术学院;
【基金】：国家自然科学基金项目(61275198,60978069,200802880013)
【分类号】：R318.51

【相似文献】