基于叠加原理的合成稳态视觉诱发电位

发布时间：2019-01-16 05:10

【摘要】：检验高刺激率诱发的稳态视觉诱发电位(SSVEP),可以被看作是低刺激率诱发的瞬态视觉诱发电位(t VEP)的线性叠加的科学假设。采用模式翻转视觉刺激,记录10名健康成年人在不同刺激率(4,7.1,7.7,8.3,9.1,10,11.1,12.5,14.3,16.7,20,25 rev/s)条件下的视觉诱发电位(VEP),然后用低刺激率(4 rev/s)诱发的t VEP及其经过幅值和相位调整后的波形,分别与刺激序列卷积合成对应高刺激率下的SSVEP,并采用Hotelling T2检验比较各t VEP模板条件下合成SSVEP与实际记录SSVEP波形之间的异同。结果显示,当使用常规记录的t VEP作为模板时,基于线性叠加原理合成的与实际记录的SSVEP在7.1~9.1 rev/s刺激率范围内不存在显著性差异(P0.05),而在10~25 rev/s刺激率范围内存在统计学差异(P0.05),且两者之间误差随刺激率增加而增大;当对t VEP模板进行幅值和相位调整后,合成与实测SSVEP之间无统计学差异(P0.05),两者间的误差也显著下降,在被测刺激率范围内基本保持平稳。结果表明,不同刺激率下的瞬态诱发反应存在差异,稳态与瞬态诱发电位之间的线性叠加假设有赖于对各个刺激率下瞬态诱发电位的测定。
[Abstract]:To test the scientific hypothesis that the steady-state visual evoked potential (SSVEP),) induced by high stimulus rate can be regarded as the linear superposition of transient visual evoked potential (t VEP) induced by low stimulus rate. Visual evoked potential (VEP),) was recorded in 10 healthy adults under different stimulus rates (47.1g / 7 7.7g / L 8.39.1g / 10 11.1L 12.5U 14.316.7 / 2025 rev/s) by using mode reversal visual stimulation. Then t VEP induced by low stimulus rate (4 rev/s) and its amplitude-phase adjusted waveforms were synthesized with convolution of stimulus sequence corresponding to SSVEP, at high stimulus rate, respectively. Hotelling T2 test was used to compare the similarities and differences between the synthetic SSVEP and the recorded SSVEP waveforms under the conditions of each t VEP template. The results showed that when t VEP was used as template, there was no significant difference between the SSVEP synthesized based on linear superposition principle and the actual record in the range of 7.1 rev/s stimulation rate (P0.05). In the range of 10 ~ 25 rev/s stimulation rate, there was statistical difference (P0.05), and the error between the two increased with the increase of stimulus rate. After adjusting the amplitude and phase of t VEP template, there was no statistical difference between synthetic and measured SSVEP (P0.05), and the error between them decreased significantly, and remained stable in the range of measured stimulus rate. The results show that there are differences in transient evoked responses under different stimulus rates. The hypothesis of linear superposition between steady-state and transient evoked potentials depends on the measurement of transient evoked potentials at different stimulus rates.
【作者单位】：南方医科大学生物医学工程学院;
【基金】：国家自然科学基金(61172033,61271154)
【分类号】：R318

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