聚氯乙烯和聚烯烃热塑性弹性体输液器对4种常用注射液稳定性及吸附性影响

发布时间：2019-04-02 08:20

【摘要】：目的:比较聚氯乙烯(PVC)输液器与聚烯烃热塑性弹性体(TPE)输液器对4种常用注射液的稳定性与吸附性的影响。方法:将乳酸环丙沙星氯化钠、左氧氟沙星氯化钠、乳酸左氧氟沙星氯化钠和托烷司琼氯化钠4种常用注射液迅速充满输液器并封存放置或正常流经输液器,采用HPLC法测定环丙沙星、左氧氟沙星和托烷司琼浓度,比较各药标示量变化,评价各药稳定性和输液器吸附性。结果:PVC和TPE输液器乳酸环丙沙星氯化钠注射液、左氧氟沙星氯化钠注射液、乳酸左氧氟沙星氯化钠注射液、托烷司琼氯化钠注射液最终(90 min)各药百分含量分别为94.11%,98.42%,98.02%,100.59%,101.91%,102.73%,99.04%,102.89%,2组含量变化无显著差异(P0.05),提示各药稳定。PVC和TPE输液器90 min各药百分含量分别为101.74%,100.21%,101.04%,99.37%和101.64%,103.10%,103.35%,103.27%,2组间含量变化无显著差异(P0.05),提示2种输液器吸附性相当。结论:PVC和TPE输液器不影响乳酸环丙沙星氯化钠注射液、左氧氟沙星氯化钠注射液、乳酸左氧氟沙星氯化钠注射液、托烷司琼氯化钠注射液的稳定性,对4种注射液中各药亦无吸附发生,可常规使用。
[Abstract]:Aim: to compare the effects of polyvinyl chloride (PVC) (PVC) infusion device and polyolefin thermoplastic elastomer (TPE) infusion device on the stability and adsorption of four kinds of common injection. Methods: ciprofloxacin lactate sodium chloride, levofloxacin lactate sodium chloride and torisetron sodium chloride were quickly filled with infusion apparatus and stored or flowing through the infusion device. The concentrations of ciprofloxacin, levofloxacin and tropisetron were determined by HPLC. The changes of the drug markers were compared, and the stability of each drug and the adsorbability of the infusion apparatus were evaluated. Results: PVC and TPE infusion apparatus ciprofloxacin lactate sodium chloride injection, levofloxacin lactate sodium chloride injection, The final (90 min) contents of troxetron sodium chloride injection were 94.11%, 98.42%, 98.02%, 100.59%, 101.91%, 102.73%, 99.04%, 102.89%, respectively. There was no significant difference between the two groups (P0.05), suggesting that each drug was stable. The percentage contents of PVC and TPE infusion at 90 min were 101.74%, 100.21%, 101.04%, 99.37% and 101.64%, 103.10%, 103.35%, respectively. There was no significant difference in the content between the two groups (P0.05), suggesting that the adsorbability of the two infusion apparatus was the same. Conclusion: PVC and TPE infusion have no effect on the stability of ciprofloxacin lactate sodium chloride injection, levofloxacin lactate sodium chloride injection and tropisetron sodium chloride injection. There was no adsorption of each drug in 4 kinds of injection, so it could be used in routine way.
【作者单位】：山东大学药学院;聊城市第二人民医院临床药学科;山东大学齐鲁医院临床药理研究所;
【分类号】：R318.6

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