巨噬细胞在生物材料植入反应及组织再生中的作用
发布时间：2019-04-17 12:16
【摘要】：生物材料在临床上有很大需求,但其植入机体后引发的炎症反应很可能会导致植入失败。巨噬细胞可调控炎症反应向诱导组织再生方向发展。在此介绍了巨噬细胞来源、亚群分类、标志物及功能,详述了生物材料植入体内后促进巨噬细胞向炎症消除和组织再生方向发展的途径与策略,对调节巨噬细胞促进组织再生研究尚需注意的问题和未来发展进行讨论。
[Abstract]:Biomaterials are in great demand in clinical practice, but the inflammatory reaction caused by implanted biomaterials is likely to lead to the failure of implantations. Macrophages can regulate the development of inflammatory response to induce tissue regeneration. In this paper, the sources of macrophages, classification of subsets, markers and functions are introduced, and the ways and strategies of promoting the development of macrophages towards inflammation elimination and tissue regeneration after biomaterials implanted in vivo are described in detail. The problems and future development of regulating macrophage promoting tissue regeneration were discussed.
【作者单位】： 药物化学生物学国家重点实验室生物活性材料教育部重点实验室南开大学生命科学学院;
【基金】：国家自然科学基金(81671842) 天津市自然科学基金(16JCZDJC37600) 教育部创新团队计划项目PCSIRT(IRT13023)
【分类号】：R318.08
[Abstract]:Biomaterials are in great demand in clinical practice, but the inflammatory reaction caused by implanted biomaterials is likely to lead to the failure of implantations. Macrophages can regulate the development of inflammatory response to induce tissue regeneration. In this paper, the sources of macrophages, classification of subsets, markers and functions are introduced, and the ways and strategies of promoting the development of macrophages towards inflammation elimination and tissue regeneration after biomaterials implanted in vivo are described in detail. The problems and future development of regulating macrophage promoting tissue regeneration were discussed.
【作者单位】： 药物化学生物学国家重点实验室生物活性材料教育部重点实验室南开大学生命科学学院;
【基金】：国家自然科学基金(81671842) 天津市自然科学基金(16JCZDJC37600) 教育部创新团队计划项目PCSIRT(IRT13023)
【分类号】：R318.08
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