构建骨组织工程支架中应用的3D打印技术

发布时间：2019-06-06 04:08

【摘要】：背景:3D打印技术自20世纪末出现以来逐渐应用在医学领域已成为一种趋势。近年来3D打印技术被广泛用于骨组织工程支架材料的成型,并取得了一些令人惊喜的成果。目的:文章从骨组织工程支架基本概念、3D打印的基本原理和流程、3D打印应用于构造支架的要求以及不同的粉末材料等方面进行阐述,分析其优势与目前存在的局限性,并对未来3D打印在骨组织工程支架中的应用进行展望。方法:第一作者应用计算机检索1990年1月至2015年2月MEDLINE数据库、Science Direct全文数据库、相关期刊论文、维普中文期刊网等有关3D打印技术在构建骨组织工程支架中应用的文章,检索词"3D打印,组织工程学,快速成型技术,支架,材料",排除重复性研究。文章共检索到52篇相关文献,其中33篇文献符合纳入标准。结果与结论:3D打印技术具有高精度、构建速度快、可按需制造实现个性化定制等优势。3D打印应用于骨组织工程支架构建时,所用的粉末或黏合剂需具备一定的条件,如流动性、稳定性与可湿性等。用于打印的粉末材料可分为人工合成多聚体、天然高分子聚合物、生物陶瓷及它们的混合物。不同粉末材料的粉末各自优缺点不同,且最终成型效果也不尽相同。3D打印技术也存在一些包括费用昂贵、不易大规模生产等方面的局限性。但尽管如此,3D打印的临床应用前景一片光明。
[Abstract]:Background: 3D printing technology has become a trend in the field of medicine since it appeared at the end of the 20th century. In recent years, 3D printing technology has been widely used in the molding of bone tissue engineering scaffolds, and some surprising results have been obtained. Objective: this paper expounds the basic concept of bone tissue engineering scaffold, the basic principle and flow chart of 3D printing, the requirements of 3D printing used in construction scaffold and different powder materials, and analyzes its advantages and limitations at present. The application of 3D printing in bone tissue engineering scaffolds in the future is prospected. Methods: the first author searched, Science Direct full-text database of MEDLINE database and Chinese periodical full-text database from January 1990 to February 2015. Articles on the application of 3D printing technology in the construction of bone tissue engineering scaffolds, such as "3D printing, tissue engineering, rapid prototyping technology, scaffolds, materials", excluding repetitive research. A total of 52 related literatures were searched, of which 33 were in accordance with the inclusion criteria. Results & conclusion: 3D printing technology has the advantages of high precision, fast construction speed and personalized customization. When 3D printing is used in the construction of bone tissue engineering scaffolds, the powder or adhesive used in the construction of bone tissue engineering scaffolds needs to have certain conditions. Such as liquidity, stability and wettability. Powder materials for printing can be divided into synthetic polymers, natural polymers, bioceramic and their mixtures. The advantages and disadvantages of different powder materials are different, and the final molding effect is not the same. 3D printing technology also has some limitations, including high cost, not easy to mass production and so on. However, the clinical application prospect of 3D printing is bright.
【作者单位】：南方医科大学第二临床医学院;南方医科大学珠江医院骨科中心;
【分类号】：R318.08;TP391.7

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