复方骨肽注射液对老年骨质疏松压缩性腰椎骨折患者骨代谢指标及疼痛的影响

发布时间：2018-03-16 20:15

本文选题：骨肽注射液　切入点：骨质疏松　出处：《中国老年学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的研究复方骨肽注射液对老年骨质疏松压缩性腰椎骨折患者骨代谢指标及疼痛的影响。方法老年骨质疏松压缩性椎体骨折患者76例均采用经皮椎体成形术治疗,根据患者自愿原则,分为复方骨肽注射液治疗的观察组38例和未使用骨肽注射液治疗的对照组38例,对比两组治疗后疼痛评分和关节功能恢复情况。结果观察组治疗后1 w、1、3、6个月静息、活动状态下的视觉模拟评分(VAS)明显低于对照组(均P0.05),治疗后观察组血清骨钙素(BGP)、甲状旁腺激素(PTH)、骨碱性磷酸醇(BALP)、Ⅰ型胶原羧基端前肽(CICP)、Ⅰ型胶原羧基端交联肽(CTX-1)、尿脱氧胶原吡啶交联(D-Pyr)改善明显且优于对照组(均P0.05),对照组各指标无明显改善(均P0.05)。结论骨肽注射液有助于改善腰椎压缩性骨折骨代谢指标,缓解患者术后疼痛。
[Abstract]:Objective to study the effects of compound osteopeptide injection on bone metabolism and pain in elderly patients with osteoporotic vertebral fractures. Methods 76 cases of senile osteoporotic vertebral fractures were treated with percutaneous vertebroplasty. According to the voluntary principle, the patients were divided into observation group (n = 38) and control group (n = 38) treated with compound osteopeptide injection. Results the pain score and the recovery of joint function were compared between the two groups. Visual analogue scores (VASs) in active group were significantly lower than those in control group (P0.05). After treatment, serum BGP, PTH, BALPU, CICPU, CTX-1C, CTX-1C were significantly lower in the observation group than those in the control group. The urine deoxycollagenopyridine crosslinked group D-Pyrr was significantly improved than that of the control group (all P 0.05, P 0.05). Conclusion Bone peptide injection is helpful to improve the bone metabolism index of lumbar vertebral compression fracture. Relieve postoperative pain.
【作者单位】：淄博市第一医院骨二科;
【分类号】：R687.3

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