间充质干细胞成骨分化中多种调控因子的交互作用及其机制

发布时间：2018-04-03 18:34

本文选题：信号通路　切入点：间充质干细胞　出处：《上海交通大学学报(医学版)》2017年05期

【摘要】：间充质干细胞(MSCs)分化为成骨细胞是骨代谢和骨修复的重要环节,其机制复杂。目前研究发现骨形态发生蛋白(BMP)、成纤维细胞生长因子(FGF)、Wnt、Hedgehog、NELL1、胰岛素样生长因子(IGF)和Notch等多种信号分子参与调控MSCs的成骨分化过程。这些信号分子自身都被证明具有较强的促进MSCs成骨分化的能力。它们能通过特异性配体激活相应受体,从而开启胞内特异的信号转导通路,促进成骨相关基因的转录、翻译过程。同时,各个信号通路之间又形成复杂的调控网络,彼此影响,共同调控MSCs的成骨分化过程。对这些信号通路相互作用机制的深入研究对于推动骨组织工程发展及治疗骨代谢疾病有重要意义。
[Abstract]:Mesenchymal stem cells (MSCs) differentiation into osteoblasts is an important part of bone metabolism and bone repair, and its mechanism is complex.At present, it has been found that several signaling molecules, such as bone morphogenetic protein (BMP), fibroblast growth factor (FGFF), and insulin like growth factor (IGF) and Notch, are involved in the process of osteogenic differentiation of MSCs.These signaling molecules have been proved to have a strong ability to promote MSCs osteogenic differentiation.They can activate the corresponding receptors through specific ligands, thus opening the intracellular specific signal transduction pathway and promoting the transcription and translation of osteoblast-associated genes.At the same time, complex regulatory networks are formed among the signaling pathways, which influence each other to regulate the osteogenic differentiation process of MSCs.It is important to study the interaction mechanism of these signaling pathways for promoting the development of bone tissue engineering and for the treatment of bone metabolic diseases.
【作者单位】：上海交通大学医学院附属新华医院老年医学科;
【基金】：国家自然科学基金(81101360) 上海市科委自然科学基金(16ZR1422000) 教育部归国留学人员启动基金(20134701)~~
【分类号】：R68

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