腰椎骨髓脂肪沉积与椎间盘退变Pfirrmann分级的相关性研究

发布时间：2018-04-06 23:02

本文选题：椎间盘　切入点：退变　出处：《临床放射学杂志》2017年12期

【摘要】：目的探讨腰椎体终板下骨髓脂肪沉积与椎间盘退变Pfirrmann分级的相关性。方法采用横断面队列研究方法,纳入研究105名志愿者,共525个椎间盘(L_(1/2)~L_5/S_1),按不同年龄段分三组,青年组(20~39岁),中年组(40~54岁),老年组(55~70岁)。对每个椎间盘行Pfirrmann分级,并采用改良水-脂分离技术(m DixonQuant)方法定量测量每个椎间盘相应上位、下位椎体终板下的脂肪分数(FF)值;对椎体骨髓FF值及椎间盘Pfirrmann分级进行统计学分析。结果不同腰椎间盘Pfirrmann分级间其上位、下位椎体终板下骨髓FF值均有显著性差异(上位椎体F=78.806,P=0.000,下位椎体F=75.459,P=0.000)。控制年龄因素,上位、下位椎体骨髓FF与腰椎间盘Pfirrmann分级均没有相关性(上位椎体:r值为0.131,P0.05;下位椎体:r值为0.111,P0.05)。不同年龄组上位椎体及下位椎体骨髓FF值与Pfirrmann分级相关性不确切;不同年龄组间及组内腰椎间盘上位及下位椎体骨髓FF值均有显著性差异(上位椎体F=265.090,P=0.000,下位椎体F=305.890,P=0.000)。结论目前尚无证据证明上位及下位椎体终板下骨髓FF值与其对应节段椎间盘退变Pfirrmann分级之间存在相关性,定量测量退变椎间盘上位及下位椎体终板下骨髓脂肪含量尚不能对椎间盘退变程度分级进行有效补充。
[Abstract]:Objective to investigate the correlation between bone marrow fat deposition and Pfirrmann grading of lumbar intervertebral disc degeneration.Methods A cross-sectional cohort study was conducted in 105 volunteers. A total of 525 patients were divided into three groups: young group (2039 years old), middle-aged group (4054 years old) and elderly group (5570 years old).Pfirrmann classification was performed on each disc, and the fat fraction of each disc was measured quantitatively by using the modified water-lipid separation technique.The FF value of vertebral bone marrow and Pfirrmann grading of intervertebral disc were analyzed statistically.Results there were significant differences in FF value of bone marrow between different Pfirrmann classification of lumbar intervertebral disc and inferior vertebral body endplate (P < 0. 000 in upper vertebral body and 75. 459% in lower vertebral body respectively), in upper vertebral body (78.806) and in lower vertebra (75. 459%), there was no significant difference in FF value between upper and lower lumbar intervertebral disc (P < 0. 000).There was no correlation between bone marrow FF and Pfirrmann grading of lumbar intervertebral disc in upper and lower vertebrae (P 0.05 for upper vertebral body and 0.131% for upper vertebra, 0.111% for lower vertebral body and 0.111% for lower vertebra).Conclusion at present, there is no evidence to prove the correlation between the FF value of bone marrow in superior and inferior vertebral body and the corresponding Pfirrmann grading of intervertebral disc degeneration.Quantitative measurement of bone marrow fat content in superior and inferior endplate of degenerative intervertebral disc can not effectively supplement the grading of degenerative degree of intervertebral disc.
【作者单位】：南方医科大学第三附属医院医学影像科;广东省佛山市妇幼保健院放射科;中山大学附属第五医院医学影像部;
【基金】：南方医科大学临床研究培育项目(编号:LC2016PY050) 广东省科技计划项目(编号:2014A020212496)
【分类号】：R445.2;R681.5

【相似文献】