体内腰椎间盘退变动物模型的研究与进展

发布时间：2018-07-03 14:32

本文选题：腰椎 + 椎间盘退化　；参考：《中国组织工程研究》2017年11期

【摘要】：背景:良好的腰椎间盘退变动物模型的建立,可以生动直观的帮助医疗工作者理解腰椎间盘退行性改变的病理生理变化以及疾病的发生发展规律,并可以通过成熟的退变模型,探索研究更有效的治疗方式。目的:综述近年国内外体内腰椎间盘退变动物模型的研究进展。方法:第一作者应用计算机检索至2016年5月为止的Pub Med数据库、相关期刊论文相关文章,英文检索词"lumbar disc,degeneration,animal model,vivo model";中文检索词"腰椎间盘,退行性病变,动物模型,在体模型"。共检索到161篇相关文献,49篇文献符合纳入标准。结果与结论:(1)建立一种直观可靠的椎间盘退变动物模型将助力腰椎间盘退变疾病的各项基础研究,并为腰椎间盘退变的修复治疗提供良好的实验载体;(2)经过80余年的发展,腰椎间盘退变的动物模型已形成了物种多、方法全、思路新的制作模式。现行制作模型各具优势,不可替代,但还存在可控性不强,安全度不高或观察周期长等问题,这些都需要进一步研究探索。
[Abstract]:Background: the establishment of a good animal model of lumbar disc degeneration can help medical workers to understand the pathophysiological changes of lumbar disc degeneration and the occurrence and development of the disease. To explore more effective treatment methods. Objective: to review the progress of animal models of lumbar disc degeneration at home and abroad in recent years. Methods: the first author searched the Pub Med database by computer until May 2016, related articles in the full text database of Chinese periodicals, the English key word was "lumbar discade generation animal model in vivo", the Chinese key words "lumbar intervertebral disc, degenerative disease, animal model, animal model", and the Chinese key words were "lumbar disc, degenerative disease, animal model, animal model". In vivo model. A total of 161 related articles were found to meet the inclusion criteria. Results & conclusion: (1) the establishment of an intuitionistic and reliable animal model of disc degeneration will contribute to the basic research of lumbar disc degeneration and provide a good experimental carrier for the repair of lumbar disc degeneration. (2) after more than 80 years of development, The animal model of lumbar disc degeneration has formed a new model with many species, complete methods and ideas. The current models have their own advantages and cannot be replaced, but there are still some problems, such as low controllability, low safety degree or long observation period, which need to be further studied and explored.
【作者单位】：北京中医药大学东直门医院骨1科;
【基金】：教育部直属高校自然科学研究面上项目(2015-JYB-JSMS065)~~
【分类号】：R-332;R681.5

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