普拉洛芬滴眼液治疗中重度干眼病抗炎作用的共聚焦显微镜观察

发布时间：2018-01-02 05:25

本文关键词：普拉洛芬滴眼液治疗中重度干眼病抗炎作用的共聚焦显微镜观察　出处：《航空航天医学杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的应用共聚焦显微镜观察0.1%普拉洛芬滴眼液治疗中重度干眼病患者的抗炎作用。方法将24例中重度干眼病患者随机分为试验组(使用0.1%普拉洛芬滴眼液和0.1%玻璃酸钠滴眼液)和对照组(使用0.1%玻璃酸钠滴眼液),治疗前及治疗后观察OSDI评分、泪膜破裂时间(BUT)及泪液分泌试验(Schirmer I试验);应用活体共聚焦显微镜(IVCM)拍摄中央角膜基底下树突状细胞并使用Image J软件计算其密度,各项指标比较采用χ2检验和t检验。结果治疗6周后,试验组树突状细胞密度(44.1±38.4)较治疗前(146.1±121.2)显著降低,差异有统计学意义(P0.05),OSDI评分(20.4±3.1)较治疗前(36.2±6.6)明显降低,差异有统计学意义(P0.05);BUT均较治疗前延长;Sehirmer I试验无明显变化。结论使用0.1%普拉洛芬滴眼液治疗中重度干眼病能够显著减轻角膜炎症。
[Abstract]:Objective to observe the anti-inflammatory effect of 0.1% Praprofen eye drops on moderate and severe xerophthalmia patients with confocal microscope. Methods 24 patients with moderate and severe xerophthalmia were randomly divided into two groups. 0.1% Praprofen eye drops and 0.1% sodium hyaluronate eye drops and control group (0.1% sodium hyaluronate eye drops) were used. OSDI score, tear film rupture time and tear secretion test were observed before and after treatment. In vivo confocal microscope (IVCM) was used to photograph the central corneal subbasal dendritic cells. The density of dendritic cells was calculated by Image J software. Results after 6 weeks of treatment, the density of dendritic cells in the experimental group was 44.1 卤38.4, which was significantly lower than that in the control group (146.1 卤121.2). The difference was statistically significant (P 0.05) and OSDI score (P 0.05 卤3.1) was significantly lower than that before treatment (36.2 卤6.6), and the difference was statistically significant (P 0.05). BUT was longer than that before treatment. Conclusion 0.1% Praprofen eye drops can significantly reduce corneal inflammation in the treatment of moderate and severe xerophthalmia.
【作者单位】：哈尔滨二四二医院眼科;
【分类号】：R777.34
【正文快照】： 干眼病在我国的发病率约为21%~33.7%[1]。炎症在干眼病的发病中起到重要的作用,研究表明在干眼患者的泪液和眼表组织中各种炎症介质表达的增加,能够对眼表的结构和功能造成了损伤[2-4]。因此,抑制眼表的免疫炎症反应成为治疗干眼的重要策略之一。糖皮质激素治疗中重度干眼症患

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