大环内酯类药物治疗慢性鼻-鼻窦炎的Meta分析

发布时间：2018-01-02 06:08

  本文关键词：大环内酯类药物治疗慢性鼻-鼻窦炎的Meta分析　出处：《中国耳鼻咽喉头颈外科》2016年11期 　论文类型：期刊论文

  更多相关文章： 鼻窦炎 大环内酯类 Meta分析

【摘要】：目的系统评价大环内酯类药物治疗慢性鼻-鼻窦炎(CRS)的临床疗效及安全性。方法计算机检索Pub Med、OVID、EMBASE、中国学术期刊全文数据库、万方数据库中关于大环内酯类药物治疗CRS的随机对照试验(Randomized controlled trials,RCT),同时追索纳入文献的参考文献。检索年限均从建库检索至2016年1月。由2名评价员独立筛查文献,对纳入的文献进行质量评价,并提取资料,对符合质量标准的RCTs进行Meta分析,比较大环内酯类药物组与安慰剂组鼻腔鼻窦结局评分(sinonasal outcome test,SNOT)、患者反应量表评分和安全性评估。统计学分析采用Rev Man5.3软件。结果共纳入3篇RCTs,Met a分析结果显示,长期低剂量应用大环内酯类药物第24周时患者SNOT评分(WMD=-0.43,P=0.03)降低,第12周时SNOT变化(WMD=-0.23,P=0.25)和患者反应量表评分变化(WMD=-0.40,P=0.28)无统计学意义。大环内酯类药物的不良反应发生率与安慰剂组相似。结论长期低剂量应用大环内酯类药物不能明显改善CRS患者的临床症状,其不良反应发生率与对照组相近。
[Abstract]:Objective to evaluate the clinical efficacy and safety of macrolides in the treatment of chronic rhinosinusitis. Chinese academic journal full-text database, Wanfang database on macrolides drug treatment of CRS randomized controlled trial of controlled trials. The retrieval years were from the construction of the database to January 2016. Two evaluators independently screened the literature, evaluated the quality of the included documents, and extracted the data. Meta analysis was performed on RCTs that met the quality standard. The sinonasal outcome test was compared between the macrolides group and the placebo group. Rev Man5.3 software was used for statistical analysis. The results were included in the results of 3 RCTsMet a analysis. The SNOT score of patients with macrolides was decreased at the 24th week (WMD-0.43P0. 03) and the change of SNOT at the 12th week (WMD-0.23). (P = 0.25) and WMD-0.40. The incidence of adverse reactions of macrolides was similar to that of placebo group. Conclusion long term low dose of macrolides can not improve the clinical symptoms of patients with CRS. The incidence of adverse reactions was similar to that of the control group.
【作者单位】： 山西医科大学第一医院耳鼻咽喉头颈外科;
【分类号】：R765
【正文快照】： Ef f icacy of macrol ides in the treatment of chronicrhinosinusitis:A meta-analysisNIU Huihui,CHAI XiangbinDepartment of Otolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University,Taiyuan,Shanxi,030000,China慢性鼻-鼻窦炎(CRS)是，

本文编号：1367984