消旋山莨菪碱滴眼液在青少年近视治疗中的应用效果分析

发布时间：2018-01-10 15:03

本文关键词：消旋山莨菪碱滴眼液在青少年近视治疗中的应用效果分析　出处：《中华全科医学》2016年06期 　论文类型：期刊论文

【摘要】：目的观察消旋山莨菪碱滴眼液治疗青少年近视的效果。方法选择2012年12月—2014年3月期间于丽水市中心医院视光门诊就诊的青少年患者共166例(近视患眼332眼),按随机对照原则均分为A组与B组。A组患者在戴镜基础上加用0.05%消旋山莨菪碱滴眼液,B组患者仅戴镜。1年后比较2组患者视力情况以及不良反应的发生情况。结果 A组患者平均原镜视力为5.01±0.03,B组患者平均原镜视力为4.82±0.09,A组高于B组(t=10.504,P0.05)。A组患者屈光度改变(0.07±0.02)D,B组患者屈光度改变(0.49±0.11)D,A组屈光度改变低于B组(t=18.051,P0.05)。A组患者眼轴变化(0.09±0.04)mm,B组患者眼轴变化(0.14±0.04)mm,A组患者眼轴变化低于B组(t=3.647,P0.05)。A组患者眼压(15.01±2.30)mm Hg(1 mm Hg=0.133 k Pa),B组患者眼压(14.97±2.11)mm Hg,组间比较差异无统计学意义(t=1.181,P0.05)。A组患者治疗后视力提高77眼,视力不变117眼,视力下降138眼,视力下降率41.57%,B组患者治疗后视力提高24眼,视力不变57眼,视力下降251眼,视力下降率75.60%,A组的视力下降率低于B组(χ~2=19.015,P0.05)。A组患者用药后未出现明显畏光、视物模糊、眼痛、眼痒等现象,裂隙灯检查无明显异常。结论采用0.05%消旋山莨菪碱滴眼液治疗青少年近视效果确切,安全性好,值得临床推广。
[Abstract]:Objective to observe the efficacy of racemic anisodamine eye drops in the treatment of juvenile myopia. Methods from December 2012 to March 2014, 166 adolescent patients in Lishui Central Hospital were selected. Example (. Myopia (332 eyes). According to the principle of random control, patients in group A and group B were divided into group A and group B. patients in group A were given 0.05% racemic anisodamine eye drops on the basis of wearing glasses. One year later, the visual acuity and adverse reaction of the two groups were compared. Results the average primary visual acuity of group A was 5.01 卤0.03. The mean primary visual acuity of group B was 4.82 卤0.09 渭 g / L, which was higher than that of group B (10.504) P 0.05A. The diopter of group A was 0.07 卤0.02D. The diopter changes in group B were 0.49 卤0.11g / d, and those in group A were lower than those in group B (P < 0.01). The change of eye axis in group A was 0.09 卤0.04mm and that in group B was 0.14 卤0.04mm. The change of eye axis in group A was lower than that in group B (3.647). Intraocular pressure (IOP) was 15.01 卤2.30mm Hg(1 Hg=0.133 k Pa. in P0.05A group. The intraocular pressure of group B was 14.97 卤2.11mm Hg.There was no significant difference between the two groups. The visual acuity of group A improved 77 eyes after treatment. The visual acuity was unchanged in 117 eyes and decreased in 138 eyes. In group B, the visual acuity was improved in 24 eyes, the visual acuity was unchanged in 57 eyes, and the visual acuity was decreased in 251 eyes. The decrease rate of visual acuity in group A was lower than that in group B (蠂 ~ 2 ~ 2 ~ (19.015) P _ (0.05)). Group A had no obvious photophobia, blurred vision and eye pain. Conclusion 0.05% racemic anisodamine eye drops are effective and safe in the treatment of juvenile myopia.
【作者单位】：丽水市中心医院眼科;
【基金】：浙江省丽水市科学技术局二类项目(2012ZC022)
【分类号】：R778.11
【正文快照】： 近视是全球范围内发生率较高的一种眼科疾病,近些年的统计结果显示,我国国内青少年近视发生率已上升至世界第2位,并且发生年龄呈现愈来愈低的趋势[1]。由于青少年时期视觉系统发育尚不完善,若患近视,则往往进展速度极快,对青少年患者日后的身心健康发育均可能造成较为严重的不

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