降钙素原及白介素-6测定在急性扁桃体炎合并脓毒症患儿中的诊断价值研究

发布时间：2018-01-16 15:14

  本文关键词：降钙素原及白介素-6测定在急性扁桃体炎合并脓毒症患儿中的诊断价值研究　出处：《中华医院感染学杂志》2017年05期 　论文类型：期刊论文

  更多相关文章： 脓毒症 急性扁桃体炎 降钙素原 白介素- 诊断

【摘要】：目的研究降钙素原及白介素-6测定在小儿急性扁桃体炎并脓毒症患儿中的诊断价值。方法选取2013年6月-2015年7月急性扁桃体炎并脓毒症患儿86例为脓毒症组,急性扁桃体炎患儿90例为扁桃体炎组、健康儿童44例为对照组;分别对患儿进行降钙素原(PCT)、白介素-6(IL-6)、C-反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞比值(N)水平以及急性生理与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分测定,比较其结果在三组中治疗前、第3天、第5天及治疗结束变化情况。结果治疗前,脓毒症组、扁桃体炎组PCT为(14.92±3.84)ng/mL、(11.10±1.00)ng/mL、IL-6为(365.20±78.00)ng/L、(262.20±47.00)ng/L)、CRP为(19.48±2.00)mg/L、(16.20±2.32)mg/L、WBC为(18.50±7.40)×109/L、(11.60±2.40)×109/L、N为(85.00±4.70)%、(78.00±2.15)%水平以及APACHEⅡ评分(20.60±4.20)分、(14.61±2.10)分,均高于对照组,差异有统计学意义(P0.05);脓毒症组,治疗第3天各项指标(PCT(25.12±4.10)ng/mL、IL-6(468.20±64.00)ng/L、CRP(24.60±3.10)mg/L、WBC(22.72±2.10)×109/L、N(89.00±3.84)%水平以及APACHEⅡ评分(27.10±3.10)分,均高于治疗前;治疗第5天(PCT(13.05±2.16)ng/mL、IL-6(80.50±4.10)ng/L、CRP(14.20±3.30)mg/L、WBC(7.20±1.00)×109/L、N(89.00±3.84)%水平以及APACHEⅡ评分(14.20±3.30)分,低于治疗第3天;治疗第3天和第5天,各项指标高于扁桃体炎组,差异有统计学意义(P0.05);治疗结束,与扁桃体炎组比较,差异无统计学意义。结论 PCT及IL-6检测有助于小儿急性扁桃体炎合并脓毒症的早期诊断、病情评估和临床指导,且PCT、IL-6的截断值14.50ng/mL、365.50ng/L,能为临床早期诊断提供参考。
[Abstract]:Objective to study the diagnostic value of procalcitonin and interleukin-6 in children with acute tonsillitis and sepsis. Methods Children with acute tonsillitis complicated with sepsis from June 2013 to July 2015 were selected. 6 cases were sepsis group. 90 children with acute tonsillitis were in tonsillitis group and 44 healthy children as control group. The patients were treated with procalcitonin proto-PCT, interleukin-6 / IL-6 / C-reactive protein (CRP) and white blood cell count (WBC) respectively. The level of neutrophil / neutrophil ratio and the acute physiological and chronic health status scoring system 鈪，

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