Ang-1、Ang-2及其受体Tie-2在鼻咽癌患者血循环中的水平及临床意义的研究

发布时间：2018-01-20 00:36

  本文关键词： 鼻咽癌 促血管生成素1 促血管生成素2 受体Tie-2　出处：《桂林医学院》2012年硕士论文　论文类型：学位论文

【摘要】：目的：初步探讨Ang-1和Ang-2及其受体Tie-2在鼻咽癌患者血循环中的水平及其临床意义。 方法：应用酶联免疫吸附试验检测20例健康对照者及68例鼻咽癌患者(初治32例,复发16例,完全缓解20例)血清Ang-1和Ang-2及其受体Tie-2水平。 结果：初治组和复发组鼻咽癌患者血清Ang-1和Ang-2及其受体Tie-2的水平均高于完全缓解组及健康对照组(P0.01),而这些分子的含量在完全缓解组和健康对照组比较无明显差异(P0.05)。Ang-2及Tie-2的水平在鼻咽癌患者不同T分期、临床分期比较有统计学意义(P0.05),并随着鼻咽癌进展呈上升趋势；Ang-1水平在不同T分期、临床分期比较差异无统计学意义(P0.05)；在不同N分期,Ang-2水平比较有统计学意义(P0.05)。转移鼻咽癌患者血清Ang-2及Tie-2水平明显高于无转移组(P0.01)。Ⅰ+Ⅱ期鼻咽癌患者血清Ang-1/Ang-2比值高于Ⅲ+Ⅳa期(P0.01) 结论：Ang-1和Ang-2及其受体Tie-2在鼻咽癌的发生发展过程中起重要作用,并与肿瘤的侵袭转移有密切关系。
[Abstract]:Objective: to investigate the level and clinical significance of Ang-1, Ang-2 and its receptor Tie-2 in the blood circulation of patients with nasopharyngeal carcinoma (NPC). Methods: enzyme linked immunosorbent assay (Elisa) was used to detect 20 healthy controls and 68 nasopharyngeal carcinoma patients (32 cases of primary treatment and 16 cases of recurrence). The levels of serum Ang-1, Ang-2 and their receptor Tie-2 in 20 patients with complete remission. Results: the levels of serum Ang-1, Ang-2 and their receptor Tie-2 in nasopharyngeal carcinoma patients were higher than those in complete remission group and healthy control group (P 0.01). However, there was no significant difference in the content of these molecules between the complete remission group and the healthy control group. The levels of P0.05U. Ang-2 and Tie-2 in patients with nasopharyngeal carcinoma at different T stages. The clinical staging was statistically significant (P 0.05), and increased with the progression of nasopharyngeal carcinoma (NPC). There was no significant difference in Ang-1 levels between different T stages and clinical stages (P 0.05). In different N stages. The serum levels of Ang-2 and Tie-2 in patients with metastatic nasopharyngeal carcinoma were significantly higher than those in patients without metastasis (P0.01). The ratio of serum Ang-1/Ang-2 in patients with stage 鈪，

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