自体角膜缘干细胞移植术治疗复发性翼状胬肉临床观察

发布时间：2018-01-20 00:45

本文关键词： 复发性翼状胬肉自体角膜缘干细胞移植泪膜功能　出处：《山东医药》2017年16期 　论文类型：期刊论文

【摘要】：目的探讨自体角膜缘干细胞移植术治疗复发性翼状胬肉的临床疗效。方法选择单侧复发性翼状胬肉患者38例,均行自体角膜缘干细胞移植术。患者分别于术前及术后1、3、6个月行患眼及健眼泪膜功能检查,记录泪液分泌试验(SIT)长度、泪膜破裂时间(BUT)、角膜荧光染色(FL)评分,并进行干眼主观症状评分。术后随访,记录患者术后复发情况。结果与健眼比较,患眼术前SIT长度缩短、BUT降低,FL评分和干眼主观症状评分均升高(P均0.05)。与术前比较,患眼术后SIT长度、BUT逐渐升高,FL评分和干眼主观症状评分均先升高后降低。术后6个月患眼SIT长度、BUT、FL评分和干眼主观症状评分与健眼比较差异均无统计学意义(P均0.05)。术后随访6个月,2例复发,复发率为5.26%。结论自体角膜缘干细胞移植术可改善复发性翼状胬肉患者的泪膜功能,缓解其干眼症状,术后复发率较低。
[Abstract]:Objective to investigate the clinical effect of limbal stem cell autotransplantation in the treatment of recurrent pterygium. Methods 38 patients with unilateral recurrent pterygium were selected. All patients underwent limbal stem cell autotransplantation. The patients were examined for the membrane function of the affected eyes and healthy tears before and after 1 and 6 months, respectively, and the length of tear secretion test was recorded. Tear film rupture time and corneal fluorescent staining (FLL) score, and dry eye subjective symptom score. Postoperative follow-up, postoperative recurrence recorded. Results compared with healthy eyes. The preoperative SIT length shortened and but decreased. The scores of FL and dry eye subjective symptoms were increased (P < 0.05). Compared with the preoperative, the SIT length of the affected eyes increased gradually. FL score and dry eye subjective symptom score increased first and then decreased. 6 months after operation, the SIT length of the eyes was increased and but. The scores of FL and subjective symptoms of dry eyes were not significantly different from those of healthy eyes (P < 0.05). Conclusion autogenous limbal stem cell transplantation can improve tear film function and relieve dry eye in patients with recurrent pterygium.
【作者单位】：北京市平谷区医院;
【分类号】：R779.6
【正文快照】： 翼状胬肉是一种结膜纤维血管性结缔组织异常增生的慢性炎症性眼表疾病,在我国患病率达2%~5%[1],其主要临床表现为睑裂区异常增厚的球结膜及其下纤维血管组织增生,侵袭生长至角膜时可引起慢性眼球刺激症状、散光、泪膜功能不稳定及视力下降[2]。复发者术后可出现不同程度的干眼

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