老年阻塞性睡眠呼吸暂停低通气综合征患者血清hs-CRP和IL-6变化及临床意义

发布时间：2018-01-22 21:48

  本文关键词： 阻塞性睡眠呼吸暂停低通气综合征 高敏C反应蛋白 白介素-　出处：《慢性病学杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的探讨老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清中高敏C反应蛋白(hsCRP)和白介素-6(IL-6)水平检测的临床意义。方法选取2014年4月—2016年3月青岛市第八人民医院收治的137例OSAHS患者作为观察组,另外选取50例同期健康体检者作为对照组,采用免疫比浊法检测两组血清中hs-CRP水平,采用酶联吸附法(ELISA)检测IL-6水平;对OSAHS患者行持续气道正压通气(CPAP)治疗,比较治疗前后其血清中hs-CRP和IL-6水平;并采用SPSS18.0统计学软件分析,计量资料以均数±标准差(xˉ±s)表示,采用t检验,多组间比较采用方差分析,P0.05为差异有统计学意义。结果观察组患者血清中hs-CRP、IL-6水平均明显高于对照组,且观察组患者血清中hsCRP、IL-6水平随病情程度加重而升高,差异均有统计学意义(P0.05);治疗后观察组患者血清中hsCRP、IL-6水平及呼吸暂停低通气指数(AHI)均较治疗前明显降低,最低血氧饱和度(LSp O2)较治疗前明显升高,差异均有统计学意义(P0.05)。结论 OSAHS患者血清hs-CRP和IL-6水平检测有助于判断病情严重程度,且利于指导其临床治疗及判断预后。
[Abstract]:Objective to investigate the serum Gao Min C-reactive protein hsCRP (hsCRP) and interleukin-6 (IL-6) in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods from April 2014 to March 2016, 137 patients with OSAHS in Qingdao 8th people's Hospital were selected as observation group. In addition, 50 healthy persons were selected as the control group. The serum hs-CRP level was detected by immunoturbidimetry, and the IL-6 level was detected by enzyme linked adsorption assay (Elisa). Patients with OSAHS were treated with continuous positive airway pressure (CPAP). The serum levels of hs-CRP and IL-6 were compared before and after treatment. The data were expressed as mean 卤standard deviation, t test and ANOVA were used in multigroup comparison. Results the serum levels of hs-CRPnIL-6 in the observation group were significantly higher than those in the control group, and the serum hsCRP in the observation group was significantly higher than that in the control group. The level of IL-6 increased with the severity of the disease, and the difference was statistically significant (P 0.05). After treatment, the serum levels of hsCRP IL-6 and apnea hypopnea index (AHII) in the observation group were significantly lower than those before treatment. The lowest oxygen saturation (LSp O 2) was significantly higher than that before treatment. Conclusion the detection of serum hs-CRP and IL-6 levels in patients with OSAHS is helpful to judge the severity of the disease. It is helpful to guide its clinical treatment and judge its prognosis.
【作者单位】： 青岛市第八人民医院;
【分类号】：R766
【正文快照】： 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是多种因素导致的睡眠过程中上气道阻塞,反复出现呼吸变浅或暂停及间断发生的低氧血症和睡眠结构破坏为特征的一种危险性大、发病率高的睡眠呼吸障碍疾病。该病多发于老年人,65岁以上老人的发病率超过20%[1],OSAHS易导致高血压、冠心病，

本文编号：1455814