匹多莫德联合氯雷他定治疗小儿过敏性鼻炎的临床疗效及其对患儿炎性因子的影响

发布时间：2018-01-23 17:59

本文关键词： 鼻炎变应性季节性匹多莫德氯雷他定炎症趋化因子类治疗结果　出处：《中国全科医学》2017年S2期 　论文类型：期刊论文

【摘要】：目的探讨匹多莫德联合氯雷他定治疗小儿过敏性鼻炎的临床疗效及其对患儿炎性因子的影响。方法选取云南省第二人民医院2014年3月—2016年3月收治的过敏性鼻炎患儿118例,按照随机数字表法分为对照组和观察组,各59例。对照组患儿采用氯雷他定等基础治疗,观察组患儿在对照组基础上加用匹多莫德治疗,两组患儿均持续治疗4周。比较两组患儿的临床疗效、临床症状(鼻痒、流涕、鼻塞及打喷嚏)缓解时间、治疗前后症状评分及炎性因子[白介素4(IL-4)、白介素5(IL-5)、白介素12(IL-12)及肿瘤坏死因子α(TNF-α)]水平。结果观察组患儿治疗总有效率高于对照组(P0.05)。观察组患儿鼻痒、流涕、鼻塞、打喷嚏缓解时间短于对照组(P0.05)。治疗前,两组患儿鼻痒、流涕、鼻塞、打喷嚏评分比较,差异无统计学意义(P0.05);治疗后,观察组患儿鼻痒、流涕、鼻塞、打喷嚏评分低于对照组(P0.05)。治疗前,两组患儿IL-4、IL-5、IL-12及TNF-α水平比较,差异无统计学意义(P0.05);治疗后,观察组患儿IL-4、IL-5水平低于对照组,IL-12、TNF-α水平高于对照组(P0.05)。结论采用匹多莫德联合氯雷他定治疗小儿过敏性鼻炎的临床疗效确切,可有效改善患儿的临床症状,降低炎性反应,促进疾病恢复。
[Abstract]:Objective to investigate the clinical effect of pidomod combined with loratadine in the treatment of allergic rhinitis in children and its influence on inflammatory factors in children. Methods We selected the second people's Hospital of Yunnan Province from March 2014 to March 2016. 118 cases of allergic rhinitis were treated. According to the random number table method, the patients in the control group and the observation group were divided into two groups, 59 cases in each group. The children in the control group were treated with loratadine as basic therapy, and the children in the observation group were treated with pidomod on the basis of the control group. The clinical effects, clinical symptoms (nasal itch, runny nose, nasal congestion and sneezing), symptom scores and inflammatory factors were compared between the two groups for 4 weeks. [Interleukin-4 (IL-4) and IL-5 (IL-5). Results the total effective rate of treatment in the observation group was higher than that in the control group (P 0.05). Before treatment, the scores of itching, runny nose, nasal congestion and sneezing in the two groups were not significantly different (P 0.05). After treatment, the scores of nasal itch, runny nose, nasal congestion and sneeze in the observation group were lower than those in the control group (P 0.05). Before treatment, the levels of IL-4, IL-5, IL-12 and TNF- 伪 were compared between the two groups. The difference was not statistically significant (P 0.05). After treatment, the level of IL-4 and IL-5 in the observation group was lower than that in the control group. Conclusion the clinical effect of pidomod combined with loratadine in the treatment of allergic rhinitis in children is definite and can effectively improve the clinical symptoms of children with allergic rhinitis. Reduce inflammatory response and promote disease recovery.
【作者单位】：云南省第二人民医院耳鼻喉科;
【分类号】：R765.21
【正文快照】： 过敏性鼻炎是临床较常见的一种过敏性疾病,发病率达10%~20%,好发于儿童。过敏性鼻炎病程较长,且易发作,主要临床表现为鼻痒、打喷嚏等,易导致鼻窦炎、支气管哮喘等并发症[1-3],严重影响患儿的身心健康。相关研究表明,Th1/Th2细胞因子失衡与过敏性鼻炎关系密切,而匹多莫德对于T

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