湖南省肿瘤医院1992～2005年鼻咽癌住院病例生存分析

发布时间：2018-01-24 05:47

本文关键词： 鼻咽癌住院病例生存分析生存率　出处：《中南大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：分析湖南省肿瘤医院1992～2005年鼻咽癌住院病例生存情况及影响因素,为医生制订最佳治疗方案和鼻咽癌防控措施提供科学依据。方法：采用随访研究收集湖南省肿瘤医院1992年1月1日～2005年12月31日鼻咽癌住院病例的生存资料。使用Excel和SPSS15.0软件对资料进行分析。一般资料进行描述性分析。病例生存分析利用寿命表法按不同临床分期、不同治疗方式等因素,计算出不同时期的生存率。对可能影响病例生存的各类因素进行整体比较,检验方法采用Wilcoxon(Gehan)检验。单因素采用Kaplan-Meier法估计生存率和采用Log-rank方法对各组生存曲线分布是否相同进行检验；采用Cox比例风险回归模型进行多因素分析。结果：随访湖南省肿瘤医院1992～2005年鼻咽癌住院病例4600例,随访截止时间为2010年12月31日,其中生存1740例,因本病死亡2819例,因其他原因死亡12例,中途失访24例,完全失访5例,随访应答率99.89%,数据删失率38.65%。1年生存率为93.47%,3年生存率为76.50%,5年生存率为62.69%,10年生存率为44.26%,15年生存率为38.88%,中位生存期为88.56个月(7.38年)。采用Log-rank检验进行单因素分析显示不同性别、不同年龄、不同职业、不同文化程度、不同临床分期、不同首次治疗方法、不同放疗进展情况鼻咽癌病例的生存率差异均有统计学意义(P0.05)。用Cox比例风险回归模型进行多因素分析显示不同年龄、不同性别、不同职业、不同临床分期、不同首次治疗方法鼻咽癌病例的生存率差异均有统计学意义(P0.05)。鼻咽癌预后主要影响因素为年龄、性别、职业、临床分期、首次治疗方法。结论：湖南省肿瘤医院1992-2005年鼻咽癌住院病例1、3、5年生存率相对于该院1987-1991年鼻咽癌住院病例1、3、5年生存率均有不同程度的提高；且该院1992-2005年鼻咽癌住院病例生存率同国内外相关文献报道相比,已达到或超过国内同级医院水平。
[Abstract]:Objective: to analyze the survival status and influencing factors of nasopharyngeal carcinoma (NPC) inpatients in Hunan Cancer Hospital from 1992 to 2005 so as to provide scientific basis for doctors to formulate the best treatment plan and prevention and control measures for NPC. Methods:. The survival data of nasopharyngeal carcinoma (NPC) patients in Hunan Cancer Hospital from January 1st 1992 to December 31st 2005 were collected by a follow-up study. The data were analyzed by Excel and SPSS15.0 software. Case survival analysis using life table method according to different clinical stages. Different treatment methods and other factors were used to calculate the survival rate in different periods. The factors that might affect the survival of the patients were compared as a whole. The test method is Wilcoxonne Gehan. Single factor Kaplan-Meier method was used to estimate survival rate and Log-rank method was used to test whether the distribution of survival curve in each group was the same or not. Cox proportional risk regression model was used for multivariate analysis. Results: 4600 cases of nasopharyngeal carcinoma were followed up in Hunan Cancer Hospital from 1992 to 2005. The deadline of follow-up was December 31st 2010, of which 1 740 cases survived. There were 2 819 cases of death due to this disease, 12 cases of death due to other causes, 24 cases of lost visit and 5 cases of complete loss of visit. The follow-up response rate was 99.89%. The 38.65.1 year survival rate was 93.47, the 3-year survival rate was 76.500.The 5-year survival rate was 62.69, and the 10-year survival rate was 44.26%. The 15-year survival rate was 38.88 and the median survival time was 88.56 months (7.38 years). Univariate analysis with Log-rank test showed that there were different genders and different ages. Different occupations, different education levels, different clinical stages, different first treatment methods. The survival rates of nasopharyngeal carcinoma patients with different radiotherapy progression were significantly different (P 0.05). The multivariate analysis using Cox proportional risk regression model showed different ages, different genders and different occupations. The survival rates of nasopharyngeal carcinoma patients with different clinical stages and different first treatment methods were significantly different (P 0.05). The main prognostic factors of nasopharyngeal carcinoma were age, sex, occupation and clinical stage. The first treatment. Conclusion: the 5-year survival rate of nasopharyngeal carcinoma inpatients in Hunan Cancer Hospital from 1992 to 2005 was 1 / 3 compared with that of nasopharyngeal carcinoma inpatients from 1987 to 1991. The 5-year survival rate was improved in different degree. The inpatient survival rate of nasopharyngeal carcinoma in this hospital from 1992 to 2005 has reached or exceeded the level of the same grade hospital in China.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R739.63

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