老年OSAHS并发急性脑梗死患者决策功能障碍与血清HIF-1的相关性

发布时间：2018-01-30 12:41

本文关键词： 阻塞性睡眠呼吸暂停脑梗死决策障碍低氧诱导因子-　出处：《广东医学》2016年21期 　论文类型：期刊论文

【摘要】：目的分析老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)并发急性脑梗死患者决策功能障碍与血清低氧诱导因子-1(HIF-1)的相关性。方法以328例老年OSAHS并发急性脑梗死患者为研究对象,根据爱荷华赌博任务(IGT)评测结果以有决策障碍者为观察组(n=178),无决策障碍者为对照组(n=150),对两组患者年龄、性别、饮酒、文化程度、梗死部位、OSAHS程度、是否合并慢性疾病以及HIF-1等决策障碍的潜在影响因素进行单因素和多因素分析;运用X~2检验和Pearson法分析决策功能障碍与血清HIF-1的相关性。结果 HIF-1水平升高是老年OSAHS并发急性脑梗死患者决策功能障碍的影响因素;高HIF-1患者比非高HIF-1患者发生脑梗死后决策障碍的风险显著增加(X~2=4.739,P=0.029;RR=1.531,95%CI:1.092~2.096);Pearson相关分析显示HIF-1水平与IGT各阶段及总分评分呈负相关,差异有统计学意义(均P0.01)。结论血清HIF-1水平升高是老年OSAHS并发急性脑梗死患者决策功能障碍的独立危险因素,HIF-1水平与决策障碍程度有关。
[Abstract]:Objective to analyze Decision-making dysfunction and serum hypoxia inducible factor-1 (HIF-1) in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with acute cerebral infarction (ACI). Methods 328 elderly patients with OSAHS complicated with acute cerebral infarction were studied. According to the IGT of Iowa gambling task, the patients with decision making disorder were selected as the observation group and the control group as the control group. The patients in the two groups were treated with age, sex and drinking alcohol. Univariate and multivariate analysis was carried out on the educational level, the degree of OSAHS at the infarct site, whether the patients were complicated with chronic diseases and the potential influencing factors of decision-making disorders such as HIF-1. X2 test and Pearson method were used to analyze the correlation between decision making dysfunction and serum HIF-1. The increase of HIF-1 level is the influencing factor of decision-making dysfunction in elderly patients with OSAHS complicated with acute cerebral infarction. The risk of decision-making disorder after cerebral infarction in high HIF-1 patients was significantly higher than that in non-high HIF-1 patients. RRN 1.531C 95CI: 1.092 / 2.096; Pearson correlation analysis showed that the level of HIF-1 was negatively correlated with the scores of each stage and total score of IGT. Conclusion the increase of serum HIF-1 level is an independent risk factor for decision dysfunction in elderly patients with OSAHS complicated with acute cerebral infarction. The level of HIF-1 is related to the degree of decision-making obstacle.
【作者单位】：华北理工大学附属医院呼吸内科;
【基金】：河北省医学科学研究重点课题计划项目(编号:20150515)
【分类号】：R766;R743.33
【正文快照】： 低氧诱导因子-1(hypoxia inducible factor-1,HIF-1)是一种缺氧应激蛋白,它的表达和活性与细胞内氧浓度大小密切相关,在机体的缺血/缺氧性损伤中具有重要的功能[1]。目前的动物实验发现脑损伤与HIF-1的表达有相关性。阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea

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