老年阻塞性睡眠呼吸暂停低通气综合征患者工作记忆与血浆低氧诱导因子-1水平的相关性

发布时间：2018-02-01 16:00

本文关键词： 阻塞性睡眠呼吸暂停低通气综合征工作记忆低氧诱导因子　出处：《中国老年学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)老年患者工作记忆与血浆低氧诱导因子(HIF)-1水平的关系。方法采用修订的韦氏记忆量表(WMS-CR)进行评估年龄、性别及教育程度相匹配的121例OSAHS老年患者及120例对照组的工作记忆情况,采用蒙特利尔认知评估(Mo CA)标准判定两组的遗忘型轻度认知功能障碍(a MCI)情况,采用酶联免疫吸附法(ELISA)测定HIF-1的水平。结果 OSAHS组WMS-CR评测中的听故事、倒背、顺背、数字广度及积累测试评分差于对照组,Mo CA评测中视空间与执行、注意、语言、抽象、延迟回忆、命名及定向的评分差于对照组,且a MCI发生比率显著高于对照组(P0.05);OSAHS组血清HIF-1水平高于对照组(P0.05);OSAHS组a MCI患者的理解、背数和积累分测验得分差于非a MCI者,血浆HIF-1水平高于非a MCI患者(P0.05);OSAHS的程度与WMS-CR各项评分呈负相关(r=-0.52,P=0.00;r=-0.53,P=0.00;r=-0.49,P=0.01;r=-0.51,P=0.00;r=-0.55,P=0.00)与Mo CA各项评分呈负相关(r=-0.47,P=0.01;r=-0.45,P=0.01;r=-0.44,P=0.01;r=-0.56,P=0.00;r=-0.50,P=0.00;r=-0.48,P=0.01;r=-0.52,P=0.00),与血浆HIF-1水平正相关(r=0.61,P=0.00);OSAHS患者血清HIF-1水平与工作记忆评分的相关系数分别为(r=0.48,P=0.01;r=0.52,P=0.00;r=0.53,P=0.00;r=0.55,P=0.00;r=0.52,P=0.00);OSAHS组a MCI患者HIF-1水平与工作记忆评分的相关系数分别为(r=0.93,P=0.00;r=0.88,P=0.00;r=0.92,P=0.00;r=0.94,P=0.00;r=0.87,P=0.00)。结论 OSAHS患者的工作记忆损伤与HIF-1水平升高相关。
[Abstract]:Objective to analyze the relationship between working memory and plasma hypoxia inducible factor (HIF-1) in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Age was evaluated by WMS-CRS. Working memory of 121 OSAHS elderly patients and 120 control group matched with sex and education level. The status of amnesia mild cognitive impairment (MCI) in two groups was evaluated by the Montreal Cognitive Assessment (MCA) standard. The level of HIF-1 was determined by Elisa. Results in the WMS-CR evaluation of OSAHS group, the story was heard, back and back. The scores of digit span and accumulation test were worse than those of the control group in terms of visual space and execution, attention, language, abstraction, delayed recall, naming and orientation. The incidence rate of a MCI was significantly higher than that of the control group (P 0.05). The level of serum HIF-1 in OSAHS group was higher than that in control group (P 0.05). The level of plasma HIF-1 in OSAHS group was higher than that in non-a MCI group (P 0.05). There was a negative correlation between the degree of OSAHS and the scores of WMS-CR. R-0.53P0. 00. RP0. 01; R-0.51Ph 0.00; There was a negative correlation between the scores of Mo CA and r-0.55P0. 00) and there was a negative correlation between the scores of Mo CA and that of 0.47% P0. 01 (P < 0. 01). RP0. 01; R-0.44Ph. 01; R-0.56P0. 00. R-0.50, P0. 00. RP0. 01; r-0. 48; The plasma HIF-1 level was positively correlated with the plasma HIF-1 level. The correlation coefficient between the serum HIF-1 level and the working memory score in OSAHS patients was 0.48% (P < 0.01). 0.52% P ~ (2 +) P ~ (2 +); 0.53% P ~ (2 +) (P ~ (2 +)); Rhizoma 0.55 (P0. 005); Rhizoma 0.52, P0. 00m; The correlation coefficient between the HIF-1 level and the working memory score in the OSAHS group was 0.93%. RP0. 8. 8, P0. 00. R = 0.92, P ~ (2 +) 0.00; R = 0.94%, P ~ (2 +) = 0.004; Conclusion the working memory impairment in patients with OSAHS is related to the increase of HIF-1 level.
【作者单位】：遵化市人民医院;华北理工大学护理与康复学院;
【分类号】：R766
【正文快照】： 1华北理工大学护理与康复学院工作记忆是指在解决认知任务的过程中,用于信息加工并同时保持与当前任务相关的信息的能量有限的系统或机制,对言语、推理等高级认知功能具有极为重要的作用〔1〕。研究显示阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者易出现认知功能障碍,表现为注

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