OSAHS患者胰岛素抵抗指数变化及其与血清炎症因子水平的相关性

发布时间：2018-02-03 06:01

本文关键词： 阻塞性睡眠呼吸暂停低通气综合征胰岛素抵抗指数炎症因子肿瘤坏死因子白细胞介素核因子κB 缺氧诱导因子　出处：《山东医药》2017年07期 　论文类型：期刊论文

【摘要】：目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者胰岛素抵抗(IR)指数变化,分析IR指数与患者血清炎症因子水平的相关性。方法 OSAHS患者122例,根据睡眠检测结果分为轻度组36例、中度组44例、重度组42例;选择同期入院体检的健康人40例为对照组。检测各组空腹血糖、空腹胰岛素,采用稳态模型胰岛素抵抗指数(HOMA-IR)评价胰岛素抵抗情况。检测各组血清中的肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、IL-2、核因子κB(NF-κB)、缺氧诱导因子(HIF-1)、脂联素及瘦素。分析OSAHS患者HOMA-IR与血清TNF-α、IL-6、IL-2、NF-KB、HIF-1水平的关系。结果重度组、中度组HOMA-IR高于轻度组及对照组(P均0.05)。各组OSAHS患者血清NF-κB、HIF-1、IL-1、IL-6、TNF-α、瘦素水平均高于对照组,血清脂联素水平均低于对照组(P均0.05)。OSAHS患者HOMA-IR与血清NF-κB、HIF-1、IL-1、IL-6、TNF-α水平呈正相关关系(r分别为0.267、0.419、0.257、0.224、0.315,P均0.05)。结论 OSAHS患者HOMA-IR升高;血清炎症因子(TNF-a、IL-6、IL-2、NF-KB、HIF-1)水平升高可能参与了OSAHS患者胰岛素抵抗的发生。
[Abstract]:Objective to observe the changes of insulin resistance (IRI) index in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 122 patients with OSAHS were divided into mild group (36 cases), moderate group (44 cases) and severe group (42 cases). 40 healthy persons were selected as control group. Fasting blood glucose and fasting insulin were measured in each group. Insulin resistance was evaluated by homeostasis model insulin resistance index (HOMA-IRI). Serum tumor necrosis factor- 伪 (TNF- 伪) and interleukin-6 (IL-6) were detected. IL-2, NF-魏 B, HIF-1, adiponectin and leptin. HOMA-IR and serum TNF- 伪 IL-6 were analyzed in patients with OSAHS. The relationship between the level of IL-2NF-KBU HIF-1. Results severe group. HOMA-IR in moderate group was higher than that in mild group and control group (P < 0.05). Serum NF- 魏 B, HIF-1, IL-1 and IL-6 TNF- 伪 were found in patients with OSAHS. The serum adiponectin level was lower than that in the control group (P = 0.05). The serum levels of leptin and serum NF- 魏 B, HIF-1 and IL-1 were significantly lower in patients with OSAHS than those in the control group. The level of TNF- 伪 in IL-6 was positively correlated with that of 0.267, 0.419 and 0.257, 0.224 and 0.315, respectively. Conclusion HOMA-IR in patients with OSAHS is higher than that in patients with OSAHS. The elevated level of serum inflammatory factor TNF-a, IL-6, IL-2 and NF-KBU HIF-1 may be involved in the development of insulin resistance in patients with OSAHS.
【作者单位】：江汉大学附属医院武汉市第六医院;
【基金】：湖北省自然科学基金面上项目(2014CFC1019)
【分类号】：R766
【正文快照】： 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种常见的影响人们生活质量的慢性病,发病率为3%~7%[1]、随年龄增加呈上升趋势。OSAHS主要病理生理变化是睡眠时反复出现的呼吸暂停引起的慢性间歇缺氧,反复的缺氧/复氧过程引起氧化应激,激活NF-κB、缺氧诱导因子1(HIF-1)等信号途径

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