中药联合激光治疗视网膜静脉阻塞黄斑水肿的临床研究

发布时间：2018-02-23 19:04

本文关键词： 视网膜静脉阻塞黄斑水肿中药激光临床研究　出处：《南京中医药大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：客观评价中药联合激光治疗视网膜静脉阻塞黄斑水肿的临床疗效,为中药联合激光治疗视网膜静脉阻塞黄斑水肿的临床研究提供依据。方法：本研究为回顾性非随机性临床干预研究。经眼底检查、视网膜血管荧光造影(Fluorescein Fondus Angiography, FFA)、光学相干断层扫描(Optical Coherence Tomography,OCT)确诊为视网膜静脉阻塞黄斑水肿的患者30例(30眼)行中药联合激光治疗,作为治疗组,根据患者的具体情况予以黄斑水肿方为基础方随证加减,并联合激光进行治疗。在最佳矫正视力(Best Correct Visual Acuity, BCVA)、黄斑中心凹视网膜厚度(Central Subfield Thickness, CST)、黄斑容积(Cube Volume, CV)、黄斑区视网膜平均厚度(Cube Average Thickness, CAT)、黄斑区视网膜最大厚度(Cube Maximum Thickness, CMT)等方面进行治疗前后的比较,对所得数据进行统计学处理,验证中药联合激光治疗本病的疗效,分析患者性别、年龄、病程与疗效是否具有相关性,并对治疗组进行视力、黄斑区中心凹视网膜厚度、黄斑区平均视网膜厚度、黄斑容积以及黄斑区视网膜最大厚度有效率的评价。结果：1.最佳矫正视力分析：治疗组治疗前后比较p0.05,其差异有统计学意义,表明治疗组治疗后视力有所提高；2.OCT结果分析：①黄斑巾心凹视网膜厚度：治疗组前后比较为p0.05,其差异有统计学意义,表明治疗组治疗后黄斑中心凹视网膜厚度有所降低；②黄斑容积：治疗组前后比较为p0.05,其差异有统计学意义,表明治疗组治疗后黄斑容积有所降低；③黄斑区视网膜平均厚度：治疗组前后比较为p0.05,其差异有统计学意义,表明治疗组治疗后黄斑区视网膜平均厚度有所降低；④黄斑区视网膜最大厚度：治疗组前后比较为p0.05,其差异有统计学意义,表明治疗组治疗后黄斑区视网膜最大厚度有所降低；3.疗效分析：两组治疗后疗效比较p0.05,差异有统计学意义,表明治疗组疗效优于对照组。结论：巾药联合激光治疗能够有效的改善视网膜静脉阻塞黄斑水肿患者视网膜黄斑水肿的吸收,减少眼底的渗出,同时可以促进眼底出血的吸收,恢复视网膜形态,促进视功能的提高。
[Abstract]:Objective: to evaluate the clinical efficacy of Chinese medicine combined with laser in the treatment of macular edema due to retinal vein occlusion. Methods: this study was a retrospective non-random clinical intervention study. Thirty patients (30 eyes) with macular edema due to retinal vein occlusion diagnosed by fluorescein Fondus angiography (FFAA) and optical coherence tomography (Oct) were treated with traditional Chinese medicine combined with laser therapy as treatment group. According to the patient's specific situation, the macular edema prescription is added or subtracted with the syndrome. At best corrected visual acuity (BCVA), macular central foveal retinal thickness (Correct), central Subfield retinal thickness (Correct), macular volume volume (Volumec), CVS, macular mean retinal thickness (MFT), cube Average Thickness, CATT, macular area retinal maximum thickness (MFT), macular area retinal maximum thickness (MFT), macular area retinal maximum thickness (MFT), macular area retinal maximum thickness (MSRT), macular area retinal maximum thickness (MFT), macular area retinal maximum thickness (MFT), CMT and other aspects of the comparison before and after treatment, The data were statistically processed to verify the curative effect of Chinese medicine combined with laser treatment, to analyze the correlation between sex, age, course of disease and curative effect, and to carry on the visual acuity, retinal thickness of fovea in macular area, and to analyze the correlation between the patients' sex, age, course of disease and curative effect. Evaluation of mean retinal thickness, macular volume, and maximum retinal thickness of macular area. Results 1.An analysis of best corrected visual acuity (BCVA): the difference between the treatment group and the treatment group before and after treatment (p0.05) was statistically significant. The results of Oct analysis showed that the retinal thickness of macular tissue in the treatment group was p0.05, and the difference was statistically significant. The results showed that the retinal thickness of macular fovea in the treatment group was lower than that in the control group (p 0.05), and the difference was statistically significant. The results showed that the mean retinal thickness of macular area in the treatment group was significantly lower than that in the control group (p 0.05). The results showed that the mean retinal thickness of macular area in the treatment group was lower than that in the control group (p 0.05), and the difference was statistically significant. The results showed that the maximum retinal thickness of macular area in the treatment group was lower than that in the control group (P 0.05), which indicated that the therapeutic effect of the treatment group was better than that of the control group. Conclusion: the combination of towel and laser therapy can effectively improve the absorption of retinal macular edema in patients with retinal vein occlusion and macular edema, reduce the exudation of the fundus, promote the absorption of fundus hemorrhage and restore the retinal morphology. Promote the improvement of visual function.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R774.5

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