应用光学相干断层扫描量化评估糖尿病黄斑水肿的临床研究

发布时间：2018-02-23 21:12

本文关键词： 糖尿病黄斑水肿光学相干断层扫描黄斑中心凹视网膜厚度脉络膜厚度　出处：《眼科新进展》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨糖尿病黄斑水肿患者在光学相干断层扫描(optical coherence tomography,OCT)中四个量化指标的变化。方法纳入糖尿病视网膜病变患者89例(155眼),按照有无黄斑水肿分为阳性组(33例55眼)及阴性组(56例100眼),另收集正常志愿者23例(42眼)为正常对照组。所有试验对象经OCT检查,测量并分析各组黄斑中心凹视网膜厚度(central retinal thickness,CRT)、黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT)的差异,观察各组黄斑区外界膜(external limiting membrane,ELM)、椭圆体带(inner segment/outer segment,IS/OS)的连续性。结果正常对照组、阴性组、阳性组CRT分别为(219.048±16.798)μm、(217.775±26.866)μm、(280.418±74.187)μm,3组间差异有统计学意义(P0.001);3组SFCT分别为(312.893±140.559)μm、(302.080±125.287)μm、(293.745±140.517)μm,3组间差异无统计学意义(P=0.781);阴性组中黄斑区ELM连续97眼、中断3眼,阳性组连续47眼、中断8眼,两组间ELM连续性差异有统计学意义(P=0.019);阴性组中黄斑区IS/OS连续95眼、中断5眼,阳性组连续36眼、中断19眼,两组间IS/OS连续性差异有统计学意义(P0.001)。结论糖尿病黄斑水肿患者CRT增加,黄斑区ELM、IS/OS连续性遭到破坏,CRT、ELM连续性及IS/OS连续性可用于量化评估糖尿病黄斑水肿。
[Abstract]:Objective to investigate the changes of four quantitative indexes in diabetic macular edema patients by optical coherence tomography (Oct). Methods Eighty-nine patients with diabetic retinopathy were divided into positive group (33 cases) and positive group (33 cases) according to the presence or absence of macular edema. 55 eyes (55 eyes) and 56 cases (100 eyes) in negative group, and 23 cases (42 eyes) of normal volunteers were collected as normal control group. All subjects were examined by OCT. The retinal thickness of central fovea of macular retinal thicknessen and the thickness of subfoveal choroidal thicknessen of macular fovea were measured and analyzed in each group. The continuity of external limiting membrane and segment/outer segmenting segment/outer were observed in normal control group and negative group. The CRT of the positive group was 219.048 卤16.798 渭 m, 217.775 卤26.866 渭 m and 280.418 卤74.187 渭 m respectively. The SFCT of the positive group was 312.893 卤140.559 渭 m, respectively. There was no significant difference among the three groups (P 0.781a), the macular area ELM 97 eyes in the negative group, 47 eyes in the positive group, 47 eyes in the positive group, and 8 eyes in the positive group. The difference of ELM continuity between the two groups was statistically significant (P < 0.019). In the negative group, the macular area IS/OS was continuous in 95 eyes, interrupted in 5 eyes, and positive in 36 eyes, interrupted in 19 eyes. Conclusion the CRT of diabetic macular edema patients is increased, the continuity of IS/OS is destroyed and the continuity of IS/OS can be used to quantitatively evaluate diabetic macular edema.
【作者单位】：南方医科大学珠江医院眼科;
【基金】：国家自然科学基金资助(编号:81500722/H1205)~~
【分类号】：R587.2;R774.5

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